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Titolo:
Acute myeloid leukaemia in children
Autore:
Langmuir, PB; Aplenc, R; Lange, BJ;
Indirizzi:
Univ Penn, Childrens Hosp Philadelphia, Sch Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Sch Med, Philadelphia, PA 19104 USA
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 77 - 93
SICI:
1521-6926(200103)14:1<77:AMLIC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; COLONY-STIMULATING-FACTOR; ACUTE MYELOGENOUS LEUKEMIA; SEVERE CONGENITAL NEUTROPENIA; ACUTE PROMYELOCYTIC LEUKEMIA; TRANSIENT MYELOPROLIFERATIVE DISORDER; PROPHYLACTIC PLATELET TRANSFUSIONS; ACUTE LYMPHOBLASTIC-LEUKEMIA; FIRST COMPLETE REMISSION; TOTAL-BODY IRRADIATION;
Keywords:
acute myeloid leukaemia; leukaemia in children; chemotherapy; stem cell transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Langmuir, PB Univ Penn, Childrens Hosp Philadelphia, Sch Med, 34th St & Civ Ctr, Philadelphia, PA 19104 USA Univ Penn 34th St & Civ Ctr Philadelphia PA USA 19104 104 USA
Citazione:
P.B. Langmuir et al., "Acute myeloid leukaemia in children", BEST P R C, 14(1), 2001, pp. 77-93

Abstract

Acute myeloid leukaemia (AML) is characterized by a block in differentiation and an unregulated proliferation of myeloid progenitor cells. While the cause of AML in children is unknown, risk factors that have been identifiedinclude exposure to toxins such as ethanol, pesticides and dietary topoisomerase II inhibitors, prior chemotherapy with alkylating agents or topoisomerase II inhibitors, constitutional disorders such as Down's syndrome and type I neurofibromatosis, and haematopoietic failure syndromes such as Fanconi anaemia and severe congenital neutropenia. With intensified chemotherapyincluding high-dose Ara-C, followed in many cases by bone marrow transplantation, and with improvements in supportive care, current survival rates approach 50%. Future advances in paediatric AML will include better risk stratification to determine optimal treatment and targeted cytotoxic therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:24:10