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Titolo:
Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats
Autore:
Krebs-Thomson, K; Giracello, D; Solis, A; Geyer, MA;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 120, anno: 2001,
pagine: 221 - 224
SICI:
0166-4328(200105)120:2<221:PHAIID>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; REFLEX MODIFICATION; INDUCED DEFICITS; SOCIAL-ISOLATION; SCHIZOPHRENIA; HABITUATION; WISTAR; ROBUST; DOMAIN;
Keywords:
isolation rearing; startle; prepulse inhibition; schizophrenia; handling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Geyer, MA Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 93 USA
Citazione:
K. Krebs-Thomson et al., "Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats", BEH BRA RES, 120(2), 2001, pp. 221-224

Abstract

Isolation rearing is a developmentally specific non-pharmacological manipulation in rats that produces a deficit in sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle reflex. Previous research has demonstrated that the isolation rearing effect on PPI is sensitive to several factors, including the time of testing with respect to length of isolation. prepulse intensities used, strain of rats, and type of housing environment. This study tested whether handling is another factor that interacts with the isolation-rearing paradigm in PPI. Rats were housed either in the social (three rats per cage) or isolate (one rat per cage) conditions and werehandled either 1-2 times per week (minimal handling) or on a daily basis (daily handling). All rats were then tested at 8 and 10 weeks post-weaning. There was an interaction between housing and handling, In the minimal handling condition, isolation rearing produced a deficit in PPI. This effect wasabsent, however, in the daily handling condition. Thus, regular handling of rats may interfere with the observation of the isolation rearing effect on PPI and should be carefully controlled in studies using this animal modelof PPI deficits. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:28:01