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Titolo:
Learning deficits in mice with persistent Borna disease virus infection ofthe CNS associated with elevated chemokine expression
Autore:
Sauder, C; Wolfer, DP; Lipp, HP; Staeheli, P; Hausmann, J;
Indirizzi:
Univ Freiburg, Inst Med Microbiol, Dept Virol, D-79008 Freiburg, Germany Univ Freiburg Freiburg Germany D-79008 Virol, D-79008 Freiburg, Germany Univ Zurich Irchel, Dept Anat, CH-8057 Zurich, Switzerland Univ Zurich Irchel Zurich Switzerland CH-8057 H-8057 Zurich, Switzerland
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 120, anno: 2001,
pagine: 189 - 201
SICI:
0166-4328(200105)120:2<189:LDIMWP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TRANSGENIC MICE; MEMORY DEFICITS; LYMPHOCYTIC CHORIOMENINGITIS; GENE-EXPRESSION; VIRAL-INFECTION; BDV INFECTION; MURINE MODEL; WATER-MAZE; ADULT-RATS;
Keywords:
Borna disease virus; persistent infection; behavioral alteration; Morris maze; openfield activity; chemokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Hausmann, J Univ Freiburg, Inst Med Microbiol, Dept Virol, Hugstetter Str 55, D-79008 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79008 many
Citazione:
C. Sauder et al., "Learning deficits in mice with persistent Borna disease virus infection ofthe CNS associated with elevated chemokine expression", BEH BRA RES, 120(2), 2001, pp. 189-201

Abstract

Borna disease virus (BDV) is a highly neurotropic RNA virus that causes a CD8(+) T cell-mediated neurological disease in certain mouse strains. We established asymptomatic persistent central nervous system (CNS) infections in mutant C57BL/10J mice that lack functional CD8(+) T cells. When analyzed at adult age for spatial learning abilities in a water maze, BDV-infected mice showed slightly impaired escape performance while their exploratory behavior in an openfield test was indistinguishable from uninfected control mice. Histological and molecular biological analysis revealed extensive viralspread throughout the CNS of infected animals. Most neurons of the hippocampus contained viral antigen, but there was no overt loss of neurons from this structure. We found almost unchanged levels of the proinflammatory cytokines IL-1 beta and TNF-alpha, but clearly increased levels of the chemokines IP-10 and RANTES in brains of infected mice. Re-examination of water maze data revealed that only infected mice with IP-10 transcript levels above a certain threshold showed impaired performance, whereas the performance ofinfected mice with lower IP-10 levels was indistinguishable from uninfected controls. This suggests that BDV infection can disturb the function of the mammalian CNS without causing overt neuronal loss, and that the magnitudeof virus-induced chemokine production in the CNS correlates with the degree of impairment. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:17:41