Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes in dopamine efflux associated with extinction, CS-induced and d-amphetamine-induced reinstatement of drug-seeking behavior by rats
Autore:
Di Ciano, P; Blaha, CD; Phillips, AG;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Macquarie Univ, Dept Psychol, Sydney, NSW 2109, Australia Macquarie Univ Sydney NSW Australia 2109 hol, Sydney, NSW 2109, Australia
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 120, anno: 2001,
pagine: 147 - 158
SICI:
0166-4328(200105)120:2<147:CIDEAW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-ADMINISTRATION BEHAVIOR; INCREASED EXTRACELLULAR DOPAMINE; REWARD-RELATED STIMULI; NUCLEUS-ACCUMBENS; INTRAVENOUS COCAINE; CONDITIONED REINFORCEMENT; 2ND-ORDER SCHEDULE; OXIDATION CURRENTS; VENTRAL STRIATUM; SHELL;
Keywords:
chronoamperometry; dopamine; nucleus accumbens; d-amphetamine; drug self-administration; extinction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, AG Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T 1Z4
Citazione:
P. Di Ciano et al., "Changes in dopamine efflux associated with extinction, CS-induced and d-amphetamine-induced reinstatement of drug-seeking behavior by rats", BEH BRA RES, 120(2), 2001, pp. 147-158

Abstract

The present experiment employed chronoamperometry with stearate-graphite paste electrodes to monitor dopamine efflux in the nucleus accumbens during extinction and subsequent reinstatement of bar-pressing for a conditioned stimulus (CS) following presentation of a CS or following a systemic injection of d-amphetamine. Rats self-administered tl-amphetamine (0.25 mg/kg per infusion) for 3 h a day on 6 consecutive days. Each infusion was paired with a flashing light CS. On the 7th day, rats self-administered d-amphetaminefor 1 h, followed by 10 h of extinction. Presentation of the CS 2 days following extinction induced small and transient increases in responding for the CS, with no significant associated increases in DA efflux. Lower rates of responding were observed in rats that had received random presentations of the CS during d-amphetamine self-administration, and in an experimentally-naive control group. A subsequent systemic injection of J-amphetamine increased dopamine efflux in the nucleus accumbens in all groups and was most effective in reinstating bar-pressing in the CS-ri-amphetamine paired group. This is consistent with the hypothesis that exposure to psychostimulant drugs. and a drug-paired CS, can reinstate drug-seeking behavior. Together, these findings suggest that enhanced DA efflux may contribute to the reinstatement of drug-seeking behavior induced by the single administration of a psychostimulant drug, but not transient reinstatement induced by presentation of a drug-paired CS alone following extinction. (C) 2001 Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:55:53