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Titolo:
Human sperm motility stimulating activity of a sulfono glycolipid isolatedfrom Sri Lankan marine red alga Gelidiella acerosa
Autore:
Premakumara, GAS; Ratnasooriya, WD; Tillekeratne, LMV; Amarasekare, AS; Atta-Ur-Rahman;
Indirizzi:
Univ Colombo, Dept Zool, Colombo 03, Sri Lanka Univ Colombo Colombo Sri Lanka 03 ombo, Dept Zool, Colombo 03, Sri Lanka Univ Colombo, Dept Chem, Colombo 03, Sri Lanka Univ Colombo Colombo Sri Lanka 03 ombo, Dept Chem, Colombo 03, Sri Lanka CISIR, Ind Technol Inst, Nat Prod Dev Grp, Colombo, Sri Lanka CISIR Colombo Sri Lanka hnol Inst, Nat Prod Dev Grp, Colombo, Sri Lanka Univ Karachi, HEJ Res Inst Chem, Karachi 32, Pakistan Univ Karachi Karachi Pakistan 32 HEJ Res Inst Chem, Karachi 32, Pakistan
Titolo Testata:
ASIAN JOURNAL OF ANDROLOGY
fascicolo: 1, volume: 3, anno: 2001,
pagine: 27 - 31
SICI:
1008-682X(200103)3:1<27:HSMSAO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOVEMENT CHARACTERISTICS; HUMAN-SPERMATOZOA; CERVICAL-MUCUS; PENTOXIFYLLINE; FERTILIZATION; INVITRO;
Keywords:
sperm motility; stimulants; reproduction; sulfono glycolipids; red alga; Gelidiella acerosa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ratnasooriya, WD Univ Colombo, Dept Zool, Colombo 03, Sri Lanka Univ Colombo Colombo Sri Lanka 03 Colombo 03, Sri Lanka
Citazione:
G.A.S. Premakumara et al., "Human sperm motility stimulating activity of a sulfono glycolipid isolatedfrom Sri Lankan marine red alga Gelidiella acerosa", ASIAN J AND, 3(1), 2001, pp. 27-31

Abstract

Aim: To evaluate the sperm motility stimulating activity of a sulfono glycolipid (S-ACT-1) isolated from Gelidiella acerosa, a Sri Lankan marine red algae. Methods: S-ACT-1, a white amorphous powder was separated from more polar fractions of the hexane soluble of 1:1 CH2Cl2/MeOH extract and subjected to H-1, C-13 NMR and IR Spectroscopy after reverse phase HPLC for identification. Effects of S-ACT-1 on human sperm motility was assessed in vitro at 10,100 and 1000 mug/mL concentrations at 37 degreesC for 0, 5, 15, 30 and 60 min. Results: S-ACT-1 was identified as a glycolipid sulfate. The lower dose increased the sperm motilily slightly, whilst the medium dose significantly increased the motility (P < 0.05) from 5 min of incubation reaching a peak at 15 min and the stimulant effect was sustained throughout the experimentalperiod. Furthermore, the medium dose rendered 80% of the immotile viable sperm motile. In contrast, the highest dose impaired the sperm motility. Thesperm stimulating activity of S-ACT-1 was dose-dependent and had a bell-shaped dose response curve for all the 5 incubation periods. Conclusion: S-ACT-1 of Gelidiella acerosa is a Sulfono glycolipid. S-ACT-1has a potent sperm motility stimulating activity in vitro and has the potential to be developed into a sperm stimulant.

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Documento generato il 04/07/20 alle ore 05:09:16