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Titolo:
Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the national heart, lung, and blood institute twin study
Autore:
DeCarli, C; Miller, BL; Swan, GE; Reed, T; Wolf, PA; Carmelli, D;
Indirizzi:
Univ Kansas, Dept Neurol, Kansas City, KS USA Univ Kansas Kansas City KS USA Kansas, Dept Neurol, Kansas City, KS USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA SRI Int, Div Hlth Sci, Menlo Park, CA 94025 USA SRI Int Menlo Park CA USA94025 t, Div Hlth Sci, Menlo Park, CA 94025 USA Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA Indiana Univ Indianapolis IN USA 46204 Genet, Indianapolis, IN 46204 USA Boston Univ, Dept Neurol, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 n Univ, Dept Neurol, Boston, MA 02215 USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 4, volume: 58, anno: 2001,
pagine: 643 - 647
SICI:
0003-9942(200104)58:4<643:CABMCO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER LESIONS; AGE-RELATED DIFFERENCES; APOLIPOPROTEIN-E; ALZHEIMER-DISEASE; NHLBI TWIN; CARDIOVASCULAR-DISEASE; HYPERINTENSITY VOLUME; ALCOHOL-CONSUMPTION; MEMORY IMPAIRMENT; TEST-PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: DeCarli, C Univ Calif Davis, Dept Neurol, 4860 Y St,Suite 3700, Sacramento, CA 95817 USA Univ Calif Davis 4860 Y St,Suite 3700 Sacramento CA USA 95817 A
Citazione:
C. DeCarli et al., "Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the national heart, lung, and blood institute twin study", ARCH NEUROL, 58(4), 2001, pp. 643-647

Abstract

Objective: To evaluate the relative risk (RR) of mild cognitive impairment(MCI) associated with cerebrovascular risk factors and cerebrovascular-related brain changes. Design: Mild cognitive impairment was determined for the subjects of the prospective National Heart, Lung, and Blood Institute Twin Study. Quantitative measures of brain, white matter hyperintensity, cerebral infarction, apolipoprotein E genotype, and psychometric testing were obtained. Results: Subjects with MCI were older (73.5 +/-3.0 vs 72.1 +/-2.8 years), consumed less alcohol (3.7 +/-5.8 vs 7.0 +/- 10.7 drinks per week), had greater white matter hyperintensity volumes (0.56%+/-0.82% vs 0.25%+/-0.34% ofcranial volume), and had an increased prevalence of apolipoprotein E4 genotype (31.4% vs 19.2%) than normal subjects. White matter hyperintensity andthe presence of the apolipoprotein E4 genotype were associated with a significantly increased risk for MCI. When all subjects were included in the analysis, alcohol consumption was associated with a reduced risk for MCI (RR=0.93, P<.05). When subjects with a history of symptomatic cerebrovascular disease were excluded from the analysis, elevated midlife diastolic blood pressure was associated with an increased risk for MCI (RR=1.70, P<.05). Conclusions: Elevated midlife blood pressures, and the resulting increasedwhite matter hyperintensities, increase the risk for MCI in a group of community-dwelling older men to at least the same degree as apolipoprotein E4 genotype. Given the common occurrence of elevations in midlife blood pressure, early and effective treatment may be warranted to prevent late-life brain abnormalities and MCI. Moreover, since many individuals with MCI progress to clinical dementia, longitudinal evaluations of this cohort will be important.

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Documento generato il 14/07/20 alle ore 18:33:49