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Titolo:
Cluster analysis and patterns of findings on cranial magnetic resonance imaging of the elderly - The cardiovascular health study
Autore:
Longstreth, WT; Diehr, P; Manolio, TA; Beauchamp, NJ; Jungreis, CA; Lefkowitz, D;
Indirizzi:
Univ Washington, Harborview Med Ctr, Dept Neurol, Seattle, WA 98104 USA Univ Washington Seattle WA USA 98104 , Dept Neurol, Seattle, WA 98104 USA Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA Univ Washington Seattle WA USA 98104 ept Epidemiol, Seattle, WA 98104 USA Univ Washington, Dept Biostat, Seattle, WA 98104 USA Univ Washington Seattle WA USA 98104 Dept Biostat, Seattle, WA 98104 USA NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 & Clin Applicat, NIH, Bethesda, MD 20892 USA Johns Hopkins Univ, Sch Med, Dept Radiol, Neuroradiol Div, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 ol Div, Baltimore, MD 21205 USA Univ Pittsburgh, Med Ctr, Dept Radiol & Neurol Surg, Neuroradiol Div, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA g, Neuroradiol Div, Pittsburgh, PA USA Wake Forest Univ, Dept Neurol, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 4, volume: 58, anno: 2001,
pagine: 635 - 640
SICI:
0003-9942(200104)58:4<635:CAAPOF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINI-MENTAL-STATE; WHITE-MATTER FINDINGS; OLDER ADULTS; MRI FINDINGS; BRAIN; ABNORMALITIES; PEOPLE; PREVALENCE; INFARCTION; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Longstreth, WT Univ Washington, Harborview Med Ctr, Dept Neurol, Box 359775,325 9Th Ave, Seattle, WA 98104 USA Univ Washington Box 359775,325 9Th AveSeattle WA USA 98104
Citazione:
W.T. Longstreth et al., "Cluster analysis and patterns of findings on cranial magnetic resonance imaging of the elderly - The cardiovascular health study", ARCH NEUROL, 58(4), 2001, pp. 635-640

Abstract

Objective: To characterize patterns of findings on cranial magnetic resonance imaging (MRI) of the elderly using a statistical technique called cluster analysis. Subjects and Methods: The Cardiovascular Health Study is a population-based, longitudinal study of 5888 people 65 years and older. Of these, 3230 underwent cranial MRI scans, which were coded for presence of infarcts and grades for white matter, ventricles, and sulci. Cluster analysis separated participants into 5 clusters based solely on patterns of MRI findings. Participants comprising each cluster were contrasted with respect to cardiovascular risk factors and clinical manifestations. Results: One cluster was low on all the MRI findings (normal) and another was high on all of them (complex infarcts). Another cluster had evidence for infarcts alone (simple infarcts), whereas the last 2 clusters lacked infarcts, one having enlarged ventricles and sulci (atrophy) and the other having prominent white matter changes and enlarged ventricles (leukoaraiosis). Factors that distinguished these clusters in a discriminant analysis were age, sex, several measures of hypertension, internal carotid artery wall thickness, smoking, and prevalent claudication before the MRI. The atrophy group had the highest percentage of men and the normal group had the lowest. Cognitive and motor performance also differed across clusters, with the atrophy cluster performing better than may have been expected. Conclusions: These MRI patterns identified participants with different vascular disease risk factors and clinical manifestations. Results of these exploratory analyses warrant consideration in other populations of elderly people. Such patterns may provide clues about the pathophysiology of structural brain changes in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 18:37:47