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Titolo:
Cerebrovascular reactivity and subcortical infarctions
Autore:
Cupini, LM; Diomedi, M; Placidi, F; Silvestrini, M; Giacomini, P;
Indirizzi:
Univ Roma Tor Vergata, Osped S Eugenio, Neurol Clin, I-00144 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00144 eurol Clin, I-00144 Rome, Italy Univ Roma Tor Vergata, Ist Ricovero & Cura Carattere Sci S Lucia, I-00144 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00144 ci S Lucia, I-00144 Rome, Italy Univ Roma Tor Vergata, Clin Malattie Nervose & Mentali, I-00144 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00144 & Mentali, I-00144 Rome, Italy
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 4, volume: 58, anno: 2001,
pagine: 577 - 581
SICI:
0003-9942(200104)58:4<577:CRASI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL VASOMOTOR REACTIVITY; CAROTID-ARTERY OCCLUSIONS; SILENT BRAIN INFARCTION; LOW-FLOW INFARCTS; RISK-FACTORS; TRANSCRANIAL DOPPLER; ISCHEMIC STROKE; WHITE-MATTER; CO2 REACTIVITY; BLOOD-FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Cupini, LM Univ Roma Tor Vergata, Osped S Eugenio, Neurol Clin, Ple Umanesimo 10, I-00144 Rome, Italy Univ Roma Tor Vergata Ple Umanesimo 10 Rome Italy I-00144 taly
Citazione:
L.M. Cupini et al., "Cerebrovascular reactivity and subcortical infarctions", ARCH NEUROL, 58(4), 2001, pp. 577-581

Abstract

Objectives: To investigate the association between different kinds of ischemic lesions and cerebrovascular reactivity (CR) and to evaluate their relationships with the major risk factors for stroke. Subjects and Methods: We evaluated CR using the breath-holding index technique during bilateral transcranial Doppler monitoring of flow velocity in the middle cerebral arteries of 41 consecutive patients attending our clinicfor a recent, first-ever, ischemic stroke and in 15 control subjects. Based on the location of the lesion determined by computed tomography, the following 3 types of infarctions were identified: cortical (or territorial), single subcortical, and subcortical with multiple silent subcortical infarctions. Patients with a condition of severe carotid artery stenosis or occlusion, which in itself could account for altered CR, were excluded from this study. All physiological and pathologic conditions that could possibly causean impairment in CR were recorded. Results: The breath-holding index was significantly lower in the multiple subcortical infarctions group than in the control subjects (P<.001), singlesubcortical infarctions group (P<.01), and cortical infarctions group (P<.01). In all of the groups male sex (P<.05) and a history of hypertension (P<.05), regardless of whether hypertension was treated, correlated with low CR. The multiple regression analysis indicated that the only significant factor able to influence the breath-holding index was the type of lesion. Conclusions: Nonstenotic patients with first-ever stroke who had a recent symptomatic subcortical infarction associated with multiple silent infarctions seem to have an impaired cerebrovascular reserve capacity. The strong association of subcortical infarctions with multiple silent infarctions withlow CR indicates the role of small vessel vasculopathy and hypoperfusion as possible pathogenetic mechanisms of subcortical infarctions ith multiple silent infarctions.

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Documento generato il 15/07/20 alle ore 08:50:44