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Titolo:
Somatic gene therapy in the cardiovascular system
Autore:
Baumgartner, I; Isner, JM;
Indirizzi:
Univ Hosp Bern, Div Angiol, Swiss Cardiovasc Ctr, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 c Ctr, CH-3010 Bern, Switzerland Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Med Vasc Med & Biomed Res, Boston, MA 02135 USA Tufts Univ Boston MA USA 02135 asc Med & Biomed Res, Boston, MA 02135 USA
Titolo Testata:
ANNUAL REVIEW OF PHYSIOLOGY
, volume: 63, anno: 2001,
pagine: 427 - 450
SICI:
0066-4278(2001)63:<427:SGTITC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE CELLS; COLLATERAL VESSEL DEVELOPMENT; VASCULAR-PERMEABILITY FACTOR; CORONARY-ARTERY DISEASE; DNA LIPOSOME COMPLEXES; IN-VIVO; PLASMID DNA; SKELETAL-MUSCLE; NAKED DNA;
Keywords:
angiogenesis; intra-arterial gene transfer; intramuscular gene transfer; restenosis; vascular endothelial growth factor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
162
Recensione:
Indirizzi per estratti:
Indirizzo: Baumgartner, I Univ Hosp Bern, Div Angiol, Swiss Cardiovasc Ctr, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 Bern, Switzerland
Citazione:
I. Baumgartner e J.M. Isner, "Somatic gene therapy in the cardiovascular system", ANN R PHYSL, 63, 2001, pp. 427-450

Abstract

This review surveys a range of approaches using plasmid DNA encoding the 165-amino-acid isoform of vascular endothelial growth factor (phVEGF(165)) to therapeutically modulate micro- or macrovascular endothelial cells, focusing on strategies to augment postnatal collateral circulation in arterial insufficiency or to accelerate re-endothelialization after balloon angioplasty to prevent restenosis. We focus on intra-arterial and intramuscular/intramyocardial gene transfer of the VEGF(165) gene, the options that have beenmost thoroughly studied to date in patients. We review developmental and postnatal significance of the endothelial-cell-specific mitogen VEGF that has stimulated these studies and present limitations of current knowledge as well as challenges for the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:22:18