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Titolo:
The gastrins: Their production and biological activities
Autore:
Dockray, GJ; Varro, A; Dimaline, R; Wang, T;
Indirizzi:
Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3BX , Merseyside, England Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 nal Unit, Boston, MA 02114 USA
Titolo Testata:
ANNUAL REVIEW OF PHYSIOLOGY
, volume: 63, anno: 2001,
pagine: 119 - 139
SICI:
0066-4278(2001)63:<119:TGTPAB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCINE-EXTENDED GASTRIN; ENTEROCHROMAFFIN-LIKE CELLS; RAT ANTRAL MUCOSA; CANINE-G-CELLS; CHOLECYSTOKININ-B/GASTRIN RECEPTOR; HISTIDINE-DECARBOXYLASE PROMOTER; VESICULAR MONOAMINE TRANSPORTER; PHORBOL 12-MYRISTATE 13-ACETATE; PROGASTRIN-DERIVED PEPTIDES; REGENERATING-GENE PROTEIN;
Keywords:
parietal cell; enterochromaffin-like cell; gastric epithelium; gastric acid;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Dockray, GJ Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3BX , England
Citazione:
G.J. Dockray et al., "The gastrins: Their production and biological activities", ANN R PHYSL, 63, 2001, pp. 119-139

Abstract

Gastric epithelial organization and function are controlled and maintainedby a variety of endocrine and paracrine mediators. Peptides encoded by thegastrin gene are an important part of this system because targeted deletion of the gene, or of the gastrin-CCKB receptor gene, leads to decreased numbers of parietal cells and decreased gastric acid secretion. Recent studiesindicate that the gastrin precursor, preprogastrin, gives rise to a variety of products, each with a distinctive spectrum of biological activity. Theconversion of progastrin to smaller peptides is regulated by multiple mechanisms including prohormone phosphorylation and secretory vesicle pH, Progastrin itself stimulates colonic epithelial proliferation; biosynthetic intermediates (Gly-gastrins) stimulate colonic epithelial proliferation and gastric epithelial differentiation; and C-terminally amidated gastrins stimulate colonic proliferation, gastric epithelial proliferation and differentiation, and acid secretion. The effects of progastrin-derived peptides on gastric epithelial function are mediated in part by release of paracrine factors that include histamine, epidermal growth factor (EGF)-receptor ligands, and Reg. The importance of the appropriate regulation of this system is shown by the observation that prolonged moderate hypergastrinemia in transgenicmice leads to remodelling of the gastric epithelium, and in the presence of Helicobacter. to gastric cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:03:05