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Titolo:
Gastrin, CCK, signaling, and cancer
Autore:
Rozengurt, E; Walsh, JH;
Indirizzi:
Univ Calif Los Angeles, CURE Digest Dis Res Ctr, Sch Med, Dept Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
ANNUAL REVIEW OF PHYSIOLOGY
, volume: 63, anno: 2001,
pagine: 49 - 76
SICI:
0066-4278(2001)63:<49:GCSAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROCHROMAFFIN-LIKE-CELL; PROTEIN-KINASE-C; FOCAL ADHESION KINASE; CHOLECYSTOKININ-B/GASTRIN RECEPTORS; GROWTH-FACTOR RECEPTOR; SWISS 3T3 CELLS; STIMULATES CA2+ MOBILIZATION; PROGASTRIN-DERIVED PEPTIDES; ZOLLINGER-ELLISON SYNDROME; FAMILY TYROSINE KINASES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
167
Recensione:
Indirizzi per estratti:
Indirizzo: Rozengurt, E Univ Calif Los Angeles, CURE Digest Dis Res Ctr, Sch Med, Dept Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA90095 CA 90095 USA
Citazione:
E. Rozengurt e J.H. Walsh, "Gastrin, CCK, signaling, and cancer", ANN R PHYSL, 63, 2001, pp. 49-76

Abstract

Gastrin, produced by G cells in the gastric antrum, has been identified asthe circulating hormone responsible for stimulation of acid secretion fromthe parietal cell. Gastrin also acts as a potent cell-growth factor that has been implicated in a variety of normal and abnormal biological processesincluding maintenance of the gastric mucosa, proliferation of enterochromaffin-like cells, and neoplastic transformation, Here, we review the models used to study the effects of gastrin on cell proliferation in vivo and in vitro with respect to mechanisms by which this hormone might influence normal and cancerous cell growth. Specifically, human and animal models of hypergastrinemia and hypogastrinemia have been described in vivo, and several cells that express cholecystokinin (CCK)(B)/gastrin receptors have been used for analysis of intracellular signaling pathways initiated by biologically active amidated gastrins. The binding of gastrin or CCK to their common cognate receptor triggers the activation of multiple signal transduction pathways that relay the mitogenic signal to the nucleus and promote cell proliferation. A rapid increase in the synthesis of lipid-derived second messengers with subsequent activation of protein phosphorylation cascades, includingmitogen-activated protein kinase, is an important early response to these signaling peptides, Gastrin and CCK also induce rapid Rho-dependent actin remodeling and coordinate tyrosine phosphorylation of cellular proteins including the non-receptor tyrosine kinases p125(fak) and Src and the adaptor proteins p130(cas) and paxillin, This article reviews recent advances in defining the role of gastrin and CCK in the control of cell proliferation in normal and cancer cells and in dissecting the signal transduction pathways that mediate the proliferative responses induced by these hormonal GI peptides in a variety of normal and cancer cell model systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:00:53