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Titolo:
Multimodality treatment of Merkel cell carcinoma: Case series and literature review of 1024 cases
Autore:
Medina-Franco, H; Urist, MM; Fiveash, J; Heslin, MJ; Bland, KI; Beenken, SW;
Indirizzi:
Univ Alabama, Dept Surg Oncol, Birmingham, AL 35233 USA Univ Alabama Birmingham AL USA 35233 Surg Oncol, Birmingham, AL 35233 USA Univ Alabama, Dept Radiat Oncol, Birmingham, AL 35233 USA Univ Alabama Birmingham AL USA 35233 diat Oncol, Birmingham, AL 35233 USA
Titolo Testata:
ANNALS OF SURGICAL ONCOLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 204 - 208
SICI:
1068-9265(200104)8:3<204:MTOMCC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS NEUROENDOCRINE CARCINOMA; POSTOPERATIVE RADIATION-THERAPY; TRABECULAR CARCINOMA; LOCOREGIONAL CONTROL; SURGICAL-MANAGEMENT; SKIN; CHEMOTHERAPY; FEATURES; MELANOMA; CANCER;
Keywords:
Merkel cell carcinoma; surgery; radiotherapy; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Beenken, SW Univ Alabama, Dept Surg Oncol, 321 Kracke Bldg,1922 7th Ave S,Birmingham,AL 35233 USA Univ Alabama 321 Kracke Bldg,1922 7th Ave S Birmingham AL USA 35233
Citazione:
H. Medina-Franco et al., "Multimodality treatment of Merkel cell carcinoma: Case series and literature review of 1024 cases", ANN SURG O, 8(3), 2001, pp. 204-208

Abstract

Background: Merkel cell carcinoma (MCC) is an unusual and potentially aggressive cancer of the skin. There is no consensus regarding the optimal therapeutic approach, and the relative roles of surgery, radiotherapy, and chemotherapy still are controversial The aim of this study is to analyze the roles of these therapeutic options. Methods: The medical records of 16 patients with a diagnosis of localized,primary MCC treated at the University of Alabama at Birmingham were reviewed. An extensive review of the English-language literature also was performed. The Kaplan-Meier method was used to develop the survival curves. Comparisons were made using Fisher's exact test. Significance was defined as P < .05. Results: MCC presented primarily in Caucasians (98.3%) with a median age of 69 years. Immunosuppressive therapy appeared to play a role in the development of this cancer. In the UAB experience, 3-year actuarial survival was 31%. The only factor significantly associated with overall survival was thestage of disease at presentation: median survivals were 97 vs. 15 months for stages I and II, respectively (log-rank, P = .02). From the literature review, adjuvant radiotherapy was associated with a reduced risk of local recurrence (P < .00001). Conclusions: MCC is an aggressive cancer, with a high tendency for local recurrence and distant spread. Surgery and adjuvant radiotherapy appear to provide optimal local control. The role of chemotherapy remains to be defined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:59:04