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Titolo:
High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma
Autore:
Brown, RH; Scichilone, N; Mudge, B; Diemer, FB; Permutt, S; Togias, A;
Indirizzi:
Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ed, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Environm Hlth Sci, Div Physiol, Baltimore, MD21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 iol, Baltimore, MD21205 USA Johns Hopkins Med Inst, Dept Radiol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Med, Div Clin Immunol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ed, Baltimore, MD 21205 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 163, anno: 2001,
pagine: 994 - 1001
SICI:
1073-449X(200103)163:4<994:HCTEOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCISED DOG LOBES; DEEP INSPIRATION; IN-VIVO; SMOOTH-MUSCLE; METHACHOLINE; EDEMA; BRONCHOCONSTRICTION; RESPONSIVENESS; TONE; OBSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, RH Johns Hopkins Sch Publ Hlth, Room 7006,615 N Wolfe St, Baltimore, MD 21205USA Johns Hopkins Sch Publ Hlth Room 7006,615 N Wolfe St Baltimore MD USA 21205
Citazione:
R.H. Brown et al., "High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma", AM J R CRIT, 163(4), 2001, pp. 994-1001

Abstract

The effects of a deep inspiration (DI) in individuals with asthma differ from those observed in healthy subjects. It has been postulated that the beneficial effect of lung inflation is mediated by airway stretch. One hypothesis to explain the defects in the function of lung inflation in asthma is that a DI may be unable to stretch the airways. This may result from attenuation of the tethering forces between the airways and the surrounding parenchyma. In the current study, we used high-resolution computed tomography (HRCT) to examine the ability of a DI to distend the airways of subjects with asthma (n = 10) compared with healthy subjects (n = 9) at baseline and after increasing airway tone with methacholine (MCh), We found that both at baseline and after the induction of smooth muscle tone with MCh, a DI distended the airways of healthy and asthmatic subjects to a similar extent, indicating that abnormal interdependence between the lung parenchyma and the airways is unlikely to play a major role in the loss or attenuation of the beneficial effect of lung inflation that characterizes asthma. Furthermore, we observed that after constriction had already been induced by MCh, followinga DI, bronchodilation occurred in the healthy subjects but further bronchoconstriction occurred in the subjects with asthma. Our findings suggest that an abnormal excitation contraction mechanism in the airway smooth muscle of subjects with mild asthma counteracts the bronchodilatory effect of a DI. Therefore, the mechanism for reduced bronchodilation after DIs in subjects with mild asthma could be intrinsic to the airway smooth muscle.

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Documento generato il 04/04/20 alle ore 08:58:42