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Titolo:
Incidence and host determinants of probable occupational asthma in apprentices exposed to laboratory animals
Autore:
Gautrin, D; Infante-Rivard, C; Ghezzo, H; Malo, JL;
Indirizzi:
Hop Sacre Coeur, Dept Chest Med, Montreal, PQ H4J 1C5, Canada Hop Sacre Coeur Montreal PQ Canada H4J 1C5 , Montreal, PQ H4J 1C5, Canada McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Epidemiol & Biostat, Montreal, PQ, Canada McGill Univ, Dept Occupat Hlth, Montreal, PQ, Canada McGill Univ MontrealPQ Canada , Dept Occupat Hlth, Montreal, PQ, Canada
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 163, anno: 2001,
pagine: 899 - 904
SICI:
1073-449X(200103)163:4<899:IAHDOP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; INHALED HISTAMINE; SENSITIZATION; ALLERGY; IGE; WORKERS; ATOPY; METHACHOLINE; EMPLOYEES; SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gautrin, D Hop Sacre Coeur, Dept Chest Med, 5400 W Gouin, Montreal, PQ H4J1C5, Canada Hop Sacre Coeur 5400 W Gouin Montreal PQ Canada H4J 1C5 Canada
Citazione:
D. Gautrin et al., "Incidence and host determinants of probable occupational asthma in apprentices exposed to laboratory animals", AM J R CRIT, 163(4), 2001, pp. 899-904

Abstract

Laboratory animal (LA) workers are frequently affected with allergic sensitization and occupational asthma (OA). The role of preexposure host factors, in particular airway responsiveness, on the incidence of QA has not been satisfactorily studied. A prospective cohort study of 417 apprentices in animal-health technology was conducted to investigate the incidence and determinants of probable OA. Questionnaire and skin-prick tests with common and work-specific allergens were administered on entry and at followup visits (up to three) from 8 to 44 mo after starting apprenticeship. Responsiveness to inhaled methacholine was assessed at baseline and at follow-up in apprentices who developed a new specific skin sensitization and in control subjects. Preexposure host characteristics and the school attended were compared between cases and all cohort subjects not meeting the criteria for probableOA. Twenty-eight apprentices satisfied the definition for probable OA, i.e., onset of immediate skin reactivity to > 1 occupational inhalant and > 3.2-fold decrease in the provocative concentration causing a 20% reduction inFEV1 (PC20). The incidence of probable OA was 2.7% (28/1,043 person-years). Baseline immediate skin reactivity to pets (rate ratio [RR] 4.1, 95% confidence interval [CI] = 1.6 to 10.8), and bronchial responsiveness (PC20 less than or equal to 32 versus PC20 > 32 mg/ml) (RR = 2.5, 95% CI = 1.0 to 5.8) were associated with an in creased risk of probable OA; a lower FEV1 hadan apparent, protective effect (RR = 0.58, 95% CI = 0.43 to 0.78). It is concluded that apprentices in animal health show a high incidence of probable OA, and that preexposure airway caliber and responsiveness as well as sensitization to pets are associated with an increased risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 02:19:56