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Titolo:
The effect of salmeterol on markers of airway inflammation following segmental allergen challenge
Autore:
Calhoun, WJ; Hinton, KL; Kratzenberg, JJ;
Indirizzi:
Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 are Med, Pittsburgh, PA 15213 USA Univ Pittsburgh, Asthma Allergy & Airway Res Ctr, Pittsburgh, PA 15213 USAUniv Pittsburgh Pittsburgh PA USA 15213 Res Ctr, Pittsburgh, PA 15213 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 163, anno: 2001,
pagine: 881 - 886
SICI:
1073-449X(200103)163:4<881:TEOSOM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN CHALLENGE; BRONCHOALVEOLAR LAVAGE; GLUCOCORTICOID RECEPTOR; BRONCHIAL REACTIVITY; MAST-CELLS; ASTHMA; AGONISTS; LUNG; RESPONSES; BRONCHOPROVOCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Calhoun, WJ Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, UPMC MUH 628 NW, Pittsburgh, PA 15213 USA Univ Pittsburgh UPMC MUH 628 NW Pittsburgh PA USA 15213 13 USA
Citazione:
W.J. Calhoun et al., "The effect of salmeterol on markers of airway inflammation following segmental allergen challenge", AM J R CRIT, 163(4), 2001, pp. 881-886

Abstract

Inflammation is a critical component of asthma. Drugs that control asthma generally reduce the degree of airway inflammation. There is theoretical controversy surrounding the effects of beta (2)-agonists on airway inflammation, with some studies suggesting an anti-inflammatory effect, and others predicting a proinflammatory influence. We conducted a double-blind, placebo-controlled, crossover study of the effect of the long-acting beta (2)-agonist salmeterol on airway inflammation induced by segmental allergen challenge (SAC). We studied 13 allergic asthmatics controlled with as needed inhaled short-acting beta (2)-agonists alone, and used bronchoalveolar lavage 5 min and 48 h after SAC to assess airway inflammation, and the effects of salmeterol on this process. Salmeterol therapy improved FEV1, but had no significant effect on the immediate or late cellular response to SAG. One measure of superoxide production was reduced, and interleukin-4 (IL-4) was reduced in baseline samples, but other indices of airway inflammation were unchanged by salmeterol therapy. We conclude that salmeterol therapy alone does not meaningfully reduce airway inflammation induced by SAG, but equally importantly, does not result in amplified inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:49:25