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Titolo:
Effects of exercise on amino acid metabolism in patients with chronic obstructive pulmonary disease
Autore:
Engelen, MPKJ; Wouters, EFM; Deutz, NEP; Does, JD; Schols, AMWJ;
Indirizzi:
Maastricht Univ, Dept Pulmonol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands ulmonol, Maastricht, Netherlands Maastricht Univ, Dept Surg, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands pt Surg, Maastricht, Netherlands Asthma Ctr Hornerheide, Horn, Netherlands Asthma Ctr Hornerheide Horn Netherlands Hornerheide, Horn, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 163, anno: 2001,
pagine: 859 - 864
SICI:
1073-449X(200103)163:4<859:EOEOAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE METABOLISM; BODY-COMPOSITION; LUNG-DISEASE; GLUTAMATE; PLASMA; HEART; EMPHYSEMA; WEAKNESS; FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Engelen, MPKJ Univ Hosp Maastricht, Dept Pulmonol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht NetherlandsNL-6202 AZ
Citazione:
M.P.K.J. Engelen et al., "Effects of exercise on amino acid metabolism in patients with chronic obstructive pulmonary disease", AM J R CRIT, 163(4), 2001, pp. 859-864

Abstract

Depletion of fat-free mass (FFM) significantly contributes to decreased skeletal muscle weakness and impaired exercise capacity in patients with chronic obstructive pulmonary disease (COPD). FFM wasting suggests disturbancesin intermediary metabolism, confirmed by data showing profound alterationsin the skeletal muscle amino acid (AA) status in COPD at rest. To unravel whether there is a role for AAs in the mechanisms for skeletal muscle dysfunction in COPD, basic knowledge of AA metabolism in the muscle during exercise is important. We examined the effects of 20 min of exercise on AA metabolism in 14 patients with COPD and eight control subjects. Arterialized venous blood and a quadriceps femoris muscle biopsy were obtained before and immediately after exercise. FFM was not significantly different between the groups. In COPD, a significant reduction of most muscle AAs was present postexercise, whereas several plasma AAs were increased (p < 0.05). Consequently, sum AAs was reduced in muscle (20%; p < 0.01) and increased in plasma (16%, p < 0.05), suggesting an enhanced AA release from muscle in COPD during exercise. In the COPD group, the increase in plasma alanine and glutaminewas even higher postexercise (61%, p < 0.01 and 21%, p < 0.01, respectively), suggesting enhanced nitrogen efflux. This study shows that exercise alters amino acid (intermediary) metabolism in patients with COPD and independent of the presence of FFM wasting.

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Documento generato il 09/04/20 alle ore 09:38:54