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Titolo:
Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets
Autore:
Goldstein, I; Bughalo, MT; Marquette, CH; Lenaour, C; Lu, Q; Rouby, JJ;
Indirizzi:
Univ Paris 06, Dept Anesthesiol, Surg Intens Care Unit, Hop La Pitie Salpetriere, F-75013 Paris, France Univ Paris 06 Paris France F-75013 ie Salpetriere, F-75013 Paris, France Univ Paris 06, Dept Pathol, Hop La Pitie Salpetriere, F-75013 Paris, France Univ Paris 06 Paris France F-75013 ie Salpetriere, F-75013 Paris, France Univ Med, Unite INSERM 416, Inst Pasteur, Lille, France Univ Med Lille France ed, Unite INSERM 416, Inst Pasteur, Lille, France Univ Med, Dept Hosp Univ Rech Exptl, Lille, France Univ Med Lille France niv Med, Dept Hosp Univ Rech Exptl, Lille, France Hosp Dist Santarem, Gen ICU, Santarem, Portugal Hosp Dist Santarem Santarem Portugal tarem, Gen ICU, Santarem, Portugal
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 4, volume: 163, anno: 2001,
pagine: 958 - 964
SICI:
1073-449X(200103)163:4<958:MVAEDE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; END-EXPIRATORY PRESSURE; REGIONAL DISTRIBUTION; ACQUIRED PNEUMONIA; NITROGEN-DIOXIDE; CRITICALLY ILL; LUNG; DAMAGE; TISSUE; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Rouby, JJ Univ Paris 06, Dept Anesthesiol, Surg Intens Care Unit, Hop La Pitie Salpetriere, 47-83 Blvd Hop, F-75013 Paris, France Univ Paris 06 47-83Blvd Hop Paris France F-75013 Paris, France
Citazione:
I. Goldstein et al., "Mechanical ventilation-induced air-space enlargement during experimental pneumonia in piglets", AM J R CRIT, 163(4), 2001, pp. 958-964

Abstract

Mechanical ventilation-induced air-space enlargement was investigated in aporcine model of multifocal pneumonia. Following the intrabronchial inoculation of Escherichia coli, 9 piglets (22 +/- 2 kg) were ventilated with a tidal volume (VT) Of 15 ml/kg for 43 +/- 15 h. Five noninoculated piglets ventilated for 60 h with the same VT served as control animals. Following death, the lungs were fixed and lung morphometry was assessed. In inoculated animals, unventilated infected and normally ventilated noninfected pulmonarylobules coexisted. In normally ventilated lung regions (I) emphysema-like lesions were present, (2) mean alveolar area and mean linear intercept weresignificantly greater in inoculated than in control animals, and (3) the degree of alveolar distension correlated with the decrease in respiratory compliance. In unventilated lung areas (I) pseudocysts were frequent, (2) alveolar edema was rare, (3) bronchiolectasis was frequent, (4) mean bronchiolar area was greater in inoculated than in control animals, and (5) the degree of bronchiolar distension correlated with the increase in inspiratory plateau pressure. In conclusion, in piglets with severe bronchopneumonia, air-space enlargement rather than pulmonary edema was the major feature of mechanical ventilation-induced lung barotrauma and resembled lesions previously reported in critically ill patients ventilated using high inspiratory pressures.

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Documento generato il 20/01/20 alle ore 22:15:29