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Titolo:
Soluble endothelial and platelet selectins in serum and ascitic fluid of women with ovarian hyperstimulation syndrome
Autore:
Daniel, Y; Geva, E; Amit, A; Eshed-Englender, T; Bar-Am, A; Lessing, JB;
Indirizzi:
Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Cytokine Res Lab, Dept Oncol, Tel Aviv, Israel Sackler Fac Med Tel Aviv Israel e Res Lab, Dept Oncol, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 3, volume: 45, anno: 2001,
pagine: 154 - 160
SICI:
1046-7408(200103)45:3<154:SEAPSI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; NECROSIS-FACTOR-ALPHA; RECEPTOR ANTAGONIST; GROWTH-FACTOR; EXPRESSION; CYTOKINES; CELLS; INTERLEUKIN-6; ANGIOGENESIS; ESTRADIOL;
Keywords:
angiogenesis; cell adhesion molecules; cytokines; inflammation; ovulation induction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Daniel, Y 9 Gonen St, IL-53486 Givataim, Israel 9 Gonen St Givataim Israel IL-53486 IL-53486 Givataim, Israel
Citazione:
Y. Daniel et al., "Soluble endothelial and platelet selectins in serum and ascitic fluid of women with ovarian hyperstimulation syndrome", AM J REPROD, 45(3), 2001, pp. 154-160

Abstract

PROBLEM: The selectins, a group of cell adhesion molecules, are major mediators of inflammatory, immunologic, and angiogenic reactions. Their possible involvement and levels of the soluble isoform in serum and ascitic fluid of women with ovarian hyperstimulation syndrome (OHSS) were not previously evaluated. METHOD OF STUDY: This prospective, case-control study involved 16 women with OHSS. Ten matched women treated by controlled ovarian stimulation and eight healthy women with normal diagnostic laparoscopy served as controls. Serum and peritoneal fluid samples obtained from all subjects were assayed for soluble endothelial selectin (sES) and soluble platelet selectin (sPS) byspecific enzyme-linked immunosorbent assay. RESULTS: Significantly higher levels of sES (median, 17.1 [9-41] vs 9.3 [2.4-21.3] ng/mL [P = 0.03]) and sPS (median, 23 [13-277] vs 6.5 [1.6-28.7] ng/mL [P = 0.001]) were observed in the peritoneal fluid of women with OHSS than the basal levels of healthy, non-stimulated women. Women with OHSS hadsignificantly lower sES serum levels than those treated by controlled ovarian hyperstimulation without OHSS, while their sPS serum levels were comparable. CONCLUSIONS: Ascitic fluid of women with OHSS contains appreciable amountsof soluble selectins, suggesting their ovarian origin and possible involvement in the syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:00:26