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Titolo:
Analysis of the CD4 protein on human vaginal T lymphocytes
Autore:
Fidel, PL; Wormley, FL; Chaiban, J; Chesson, RR; Lounev, V;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana State Univ, Hlth Sci Ctr, Dept Obstet & Gynecol, New Orleans, LAUSA Louisiana State Univ New Orleans LA USA et & Gynecol, New Orleans, LAUSA
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 4, volume: 45, anno: 2001,
pagine: 200 - 204
SICI:
1046-7408(200104)45:4<200:AOTCPO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENOTYPICALLY DISTINCT; LANGERHANS CELLS; MURINE VAGINA; IMMUNITY; RECEPTOR; SUBSETS; CERVIX;
Keywords:
CD4 protein; mucosal immunity; T cells; vaginal mucosa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Fidel, PL Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, 1901 Perdido St, New Orleans, LA 70112 USA Louisiana State Univ 1901 Perdido St New Orleans LA USA 70112 SA
Citazione:
P.L. Fidel et al., "Analysis of the CD4 protein on human vaginal T lymphocytes", AM J REPROD, 45(4), 2001, pp. 200-204

Abstract

PROBLEM: Although T lymphocytes at the human vaginal mucosa have been partially characterized, there remains a paucity of information regarding cell-mediated immune mechanisms at this mucosal site. In mice and humans, there are several phenotypic distinctions between vaginal T lymphocytes and thosein the peripheral circulation. Recently, we observed as well that the N-terminus of the CD4 protein on murine vaginal T lymphocytes is atypically expressed compared to its systemic counterpart, and that the atypical expression extends to the mRNA level. METHOD OF STUDY: The purpose of this study was to evaluate the CD4 proteinon human vaginal T lymphocytes by flow cytometry and RT-PCR. RESULTS: Results showed that, in contrast to mice, the CD4 protein on human vaginal and peripheral blood T lymphocytes are similar at both the molecular and protein levels. CONCLUSIONS: These results indicate that based on several differences between human and mouse vaginal T cells, caution is urged when using mice as a model to study human vaginal immunity.

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Documento generato il 05/04/20 alle ore 06:55:03