Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of endothelial nitric oxide synthase in the postnatal developing porcine kidney
Autore:
Solhaug, MJ; Kullaprawithaya, U; Dong, XQ; Dong, KW;
Indirizzi:
Eastern Virginia Med Sch, Dept Pediat, Norfolk, VA 23501 USA Eastern Virginia Med Sch Norfolk VA USA 23501 diat, Norfolk, VA 23501 USA Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23501 USA Eastern Virginia Med Sch Norfolk VA USA 23501 Sci, Norfolk, VA 23501 USA Eastern Virginia Med Sch, Dept Obstet & Gynecol, Norfolk, VA 23501 USA Eastern Virginia Med Sch Norfolk VA USA 23501 ecol, Norfolk, VA 23501 USA Old Dominion Univ, Dept Chem, Norfolk, VA 23529 USA Old Dominion Univ Norfolk VA USA 23529 , Dept Chem, Norfolk, VA 23529 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: R1269 - R1275
SICI:
0363-6119(200105)280:5<R1269:EOENOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; GROWTH; HEMODYNAMICS; RESISTANCE; ISOFORMS;
Keywords:
neuronal; gene expression; protein content; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Solhaug, MJ Eastern Virginia Med Sch, Dept Pediat, POB 1980, Norfolk, VA 23501 USA Eastern Virginia Med Sch POB 1980 Norfolk VA USA 23501 501 USA
Citazione:
M.J. Solhaug et al., "Expression of endothelial nitric oxide synthase in the postnatal developing porcine kidney", AM J P-REG, 280(5), 2001, pp. R1269-R1275

Abstract

The postnatal pattern of renal endothelial nitric oxide synthase (eNOS) isunknown. The purpose of this study was to characterize eNOS expression during maturation and compare this to neuronal NOS (nNOS). The experiments measured whole kidney eNOS mRNA expression by RT-PCR and protein content by Western blot, as well as cortical and medullary protein content in piglets atselected postnatal ages and in adult pigs. Whole kidney eNOS mRNA was compared with nNOS. Whole kidney eNOS expression decreased from the newborn to its lowest at 7 days, returning by 14 days to adult levels. This eNOS mRNA pattern contrasted with nNOS, which was highest at birth, and progressivelydecreased to its lowest level in the adult. At birth, cortical eNOS protein was greater than medullary, contrasting with the adult pattern of equivalent levels. In conclusion eNOS is developmentally regulated during early renal maturation and may critically participate in renal function during thisperiod. The eNOS developmental pattern differs from nNOS, suggesting that these isoforms may have different regulatory factors and functional contributions in the postnatal kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:20:18