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Titolo:
Glucocorticoids modulate baroreflex control of renal sympathetic nerve activity
Autore:
Scheuer, DA; Mifflin, SW;
Indirizzi:
Univ Missouri, Dept Pharmacol, Kansas City, MO 64108 USA Univ Missouri Kansas City MO USA 64108 armacol, Kansas City, MO 64108 USA Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 Pharmacol, San Antonio, TX 78229 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: R1440 - R1449
SICI:
0363-6119(200105)280:5<R1440:GMBCOR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTISOL-INDUCED HYPERTENSION; ROSTRAL VENTROLATERAL MEDULLA; RENIN-ANGIOTENSIN SYSTEM; PITUITARY-ADRENAL AXIS; CUSHINGS-SYNDROME; RAT-BRAIN; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; PRESSOR RESPONSIVENESS; BLOOD-PRESSURE; HUMANS;
Keywords:
corticosterone; hypertension; sympathetic nervous system; blood pressure regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Scheuer, DA Univ Missouri, Dept Pharmacol, 2411 Holmes St,Rm MG 111, Kansas City, MO 64108 USA Univ Missouri 2411 Holmes St,Rm MG 111 Kansas City MO USA 64108
Citazione:
D.A. Scheuer e S.W. Mifflin, "Glucocorticoids modulate baroreflex control of renal sympathetic nerve activity", AM J P-REG, 280(5), 2001, pp. R1440-R1449

Abstract

Experiments were performed to determine the effects of glucocorticoids on arterial baroreceptor reflex control of renal sympathetic nerve activity (RSNA). Intravenous infusions of phenylephrine and nitroprusside were used toproduce graded changes in arterial pressure (AP) in Inactin-anesthetized male Sprague-Dawley rats. Baroreflex control of RSNA was determined during abaseline period and 2 and 3 h after administration of the glucocorticoid type II receptor antagonist Mifepristone (30 mg/kg sc) or vehicle (oil). Corticosterone (cort) treatment (100 mg cort pellet sc for 2-3 wk) increased baseline AP from 115 +/- 2 to 128 +/- 1 mmHg. Cort treatment also decreased the gain coefficient and increased the midpoint of the baroreflex curve. Treatment of cort rats with Mifepristone decreased AP within 2 h and increased the gain coefficient and decreased the midpoint of the baroreflex function curve back toward values measured in control rats. Mifepristone altered the baroreflex function curve even when AP was maintained at baseline levels. Therefore, these data demonstrate for the first time that glucocorticoidscan modulate baroreflex control of RSNA by a mechanism that is, in part, independent of changes in AP.

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Documento generato il 10/07/20 alle ore 12:48:51