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Titolo:
Vagal and spinal mechanosensors in the rat stomach and colon have multiplereceptive fields
Autore:
Berthoud, HR; Lynn, PA; Blackshaw, LA;
Indirizzi:
Louisiana State Univ, Pennington Biomed Res Ctr, Neurobiol Nutr Lab, BatonRouge, LA 70808 USA Louisiana State Univ Baton Rouge LA USA 70808 b, BatonRouge, LA 70808 USA Royal Adelaide Hosp, Dept Gastroenterol Hepatol & Gen Med, Nerve Gut Res Lab, Adelaide, SA 5000, Australia Royal Adelaide Hosp Adelaide SA Australia5000 elaide, SA 5000, Australia
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: R1371 - R1381
SICI:
0363-6119(200105)280:5<R1371:VASMIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFERENT-FIBERS; GASTROINTESTINAL-TRACT; DUODENAL MUCOSA; SMOOTH-MUSCLE; IN-VITRO; MECHANORECEPTORS; INNERVATION; FERRET; DISCHARGE; ESOPHAGUS;
Keywords:
visceral afferents; electrophysiology; chemoreceptors; gastrointestinal innervation; vagus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Berthoud, HR Louisiana State Univ, Pennington Biomed Res Ctr, Neurobiol Nutr Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA Louisiana State Univ 6400 Perkins Rd Baton Rouge LA USA 70808
Citazione:
H.R. Berthoud et al., "Vagal and spinal mechanosensors in the rat stomach and colon have multiplereceptive fields", AM J P-REG, 280(5), 2001, pp. R1371-R1381

Abstract

Mechano- and chemosensitive extrinsic primary afferents innervating the gastrointestinal tract convey important information regarding the state of ingested nutrients and specific motor patterns to the central nervous system via splanchnic and vagal nerves. Little is known about the organization of peripheral receptive sites of afferents and their correspondence to morphologically identified terminal structures. Mechano- and chemosensory characteristics and receptive fields of single vagal fibers innervating the stomachas well as lumbar splanchnic nerves innervating the distal colon were identified using an in vitro perifusion system. Twenty-three (17%) of one-hundred thirty-six vagal units identified were found to have multiple, punctate receptive fields, up to 35 mm apart, and were distributed throughout the stomach. Evidence was based on similarity of generated spike forms, occlusion, and latency determinations. Most responded with brief bursts of activity to mucosal stroking with von Frey hairs (10-200 mg) but not to stretch, and32% responded to capsaicin (10(-5) M). They were classified as rapidly adapting mucosal receptors. Four (8%) of fifty-three single units recorded from the lumbar splanchnic nerve had more than one, punctate receptive field in the distal colon, up to 40 mm apart. They responded to blunt probing, particularly from the serosal side, and variously to chemical stimulation with5-hydroxytryptamine and capsaicin. We conclude that a proportion of gastrointestinal mechanosensors has multiple receptive fields and suggest that they integrate mechanical and chemical information from an entire organ, constituting the generalists in visceral sensation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 10:48:51