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Titolo:
Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake
Autore:
De Gobbi, JIF; De Luca, LA; Johnson, AK; Menani, JV;
Indirizzi:
UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, BrazilUNESP Araraquara SP Brazil BR-14801903 BC-14801903 Araraquara, SP, Brazil Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 a, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa, Dept Pharmacol & Exercise Sci, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 & Exercise Sci, Iowa City, IA 52242 USA Univ Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USA Univ Iowa Iowa City IAUSA 52242 Ctr Cardiovasc, Iowa City, IA 52242 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: R1301 - R1307
SICI:
0363-6119(200105)280:5<R1301:IOSACI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALT APPETITE; ANGIOTENSIN-II; FOOD-INTAKE; RAT; DRINKING; PEPTIDE; CONNECTIONS; PRESSURE; INPUT;
Keywords:
5-hydroxytryptamine; proglumide; methysergide; NaCl intake; sodium appetite; angiotensin II;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Menani, JV UNESP, Sch Dent, Dept Physiol & Pathol, Rua Humaita 1680, BR-14801903 Araraquara, SP, Brazil UNESP Rua Humaita 1680 Araraquara SP Brazil BR-14801903 BCrazil
Citazione:
J.I.F. De Gobbi et al., "Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake", AM J P-REG, 280(5), 2001, pp. R1301-R1307

Abstract

Serotonin [5-hydroxytryptamine (5-HT)] and CCK injected into the lateral parabrachial nucleus (LPBN) inhibit NaCl and water intake. In this study, weinvestigated interactions between 5-HT and CCK into the LPBN to control water and NaCl intake. Male Holtzman rats with cannulas implanted bilaterallyin the LPBN were treated with furosemide + captopril to induce water and NaCl intake. Bilateral LPBN injections of high doses of the 5-HT antagonist methysergide (4 mug) or the CCK antagonist proglumide (50 mug), alone or combined, produced similar increases in water and 1.8% NaCl intake. Low dosesof methysergide (0.5 mug) + proglumide (20 mug) produced greater increasesin NaCl intake than when they were injected alone. The 5-HT2a/2c agonist 2,5-dimetoxy-4-iodoamphetamine hydrobromide (DOI; 5 mug) into the LPBN reduced water and NaCl intake. After proglumide (50 mug) + DOI treatment, the intake was not different from vehicle treatment. CCK-8 (1 mug) alone producedno effect. CCK-8 combined with methysergide (4 mug) reduced the effect of methysergide on NaCl intake. The data suggest that functional interactions between 5-HT and CCK in the LPBN may be important for exerting inhibitory control of NaCl intake.

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Documento generato il 27/11/20 alle ore 02:06:56