Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Injection of muscimol in dorsomedial hypothalamus and stress-induced Fos expression in paraventricular nucleus
Autore:
Morin, SM; Stotz-Potter, EH; DiMicco, JA;
Indirizzi:
Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 oxicol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Program Med Neurobiol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 robiol, Indianapolis, IN 46202 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: R1276 - R1284
SICI:
0363-6119(200105)280:5<R1276:IOMIDH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS; LOCUS-COERULEUS; CONSCIOUS DOGS; RAT; NEURONS; INACTIVATION; HEMORRHAGE; MECHANISMS; IDENTIFICATION; NEUROENDOCRINE;
Keywords:
adrenocorticotrophic hormone; hemorrhage; heart rate; gamma-aminobutyric acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: DiMicco, JA Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, 635 Barnhill Dr MS A419, Indianapolis, IN 46202 USA Indiana Univ 635 Barnhill Dr MS A419Indianapolis IN USA 46202
Citazione:
S.M. Morin et al., "Injection of muscimol in dorsomedial hypothalamus and stress-induced Fos expression in paraventricular nucleus", AM J P-REG, 280(5), 2001, pp. R1276-R1284

Abstract

Prior microinjection of the GABA(A)-receptor agonist muscimol into the dorsomedial hypothalamus (DMH) in conscious rats attenuates the increases in heart rate, blood pressure, and circulating adrenocorticotrophic hormone seen in air stress. Here, we examined the effect of similar treatment on air stress- or hemorrhage-induced Fos expression in the paraventricular nucleus (PVN). Muscimol (80 pmol/100 nl per side) or saline (100 nl per side) was microinjected bilaterally into the DMH in conscious rats before either air stress, an emotional or neurogenic stressor, or graded hemorrhage, a physiological stressor. Each stressor evoked a characteristic pattern of Fos expression in the parvocellular and magnocellular PVN after saline. Injection ofmuscimol into the DMH suppressed Fos expression in the PVN associated withair stress but not with hemorrhage. Injection of muscimol at sites anterior to the DMH and closer to the PVN had no effect on Fos expression in the PVN after air stress. Thus activation of neurons in the DMH is necessary forexcitation of neurons in the PVN during air stress but not during hemorrhage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:51:52