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Titolo:
NO formation in nucleus tractus solitarii attenuates pressor response evoked by skeletal muscle afferents
Autore:
Li, JH; Potts, JT;
Indirizzi:
Univ Texas, SW Med Ctr, Harry S Moss Heart Ctr, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 rry S Moss Heart Ctr, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 r, Dept Internal Med, Dallas, TX 75390 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: H2371 - H2379
SICI:
0363-6135(200105)280:5<H2371:NFINTS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; NITRIC-OXIDE SYNTHASE; GASTROCNEMIUS-SOLEUS MUSCLE; CARDIOVASCULAR CONTROL; MUSCULAR-CONTRACTION; BARORECEPTOR REFLEX; CENTRAL PATHWAYS; RAT-BRAIN; CAT; INHIBITION;
Keywords:
cardiovascular responses; static muscle contraction; blood; pressure; heart rate; microdialysis; L-arginine; L-NAME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Li, JH Univ Texas, SW Med Ctr, Harry S Moss Heart Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 , TX 75390 USA
Citazione:
J.H. Li e J.T. Potts, "NO formation in nucleus tractus solitarii attenuates pressor response evoked by skeletal muscle afferents", AM J P-HEAR, 280(5), 2001, pp. H2371-H2379

Abstract

We have previously shown that static muscle contraction induces the expression of c-Fos protein in neurons of the nucleus tractus solitarii (NTS) andthat some of these cells were codistributed with neuronal NADPH-diaphorase[nitric oxide (NO) synthase]-positive fibers. In the present study, we sought to determine the role of NO in the NTS in mediating the cardiovascular responses elicited by skeletal muscle afferent fibers. Static contraction of the triceps surae muscle was induced by electrical stimulation of the L7 and S1 ventral roots in anesthetized cats. Muscle contraction during microdialysis of artificial extracellular fluid increased mean arterial pressure (MAP) and heart rate (HR) 51 +/- 9 mmHg and 18 +/- 3 beats/min, respectively. Microdialysis of L-arginine (10 mM) into the NTS to locally increase NO formation attenuated the increases in MAP (30 +/- 7 mmHg, P < 0.05) and HR (14 +/- 2 beats/ min, P > 0.05) during contraction. Microdialysis of D-arginine (10 mM) did not alter the cardiovascular responses evoked by muscle contraction. Microdialysis of N-G-nitro-L-arginine methyl ester (2 mM) duringcontraction attenuated the effects of L-arginine on the reflex cardiovascular responses. These findings demonstrate that an increase in NO formation in the NTS attenuates the pressor response to static muscle contraction, indicating that the NO system plays a role in mediating the cardiovascular responses to static muscle contraction in the NTS.

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Documento generato il 06/04/20 alle ore 05:45:59