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Titolo:
Cerebral blood flow velocity response to induced and spontaneous sudden changes in arterial blood pressure
Autore:
Panerai, RB; Dawson, SL; Eames, PJ; Potter, JF;
Indirizzi:
Univ Leicester, Leicester Royal Infirm, Div Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW er LE1 5WW, Leics, England Univ Leicester, Glenfield Hosp, Div Med Elderly, Leicester LE3 9QP, Leics,England Univ Leicester Leicester Leics England LE3 9QP ter LE3 9QP, Leics,England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: H2162 - H2174
SICI:
0363-6135(200105)280:5<H2162:CBFVRT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY-DOMAIN ANALYSIS; VALSALVA MANEUVER; SPONTANEOUS FLUCTUATIONS; AUTOREGULATION DYNAMICS; HUMANS; HEMODYNAMICS; CIRCULATION; RESISTANCE; STENOSIS;
Keywords:
cerebral circulation; cerebrovascular resistance; cerebral autoregulation; thigh cuff test; cold pressor test; hand grip; Valsalva maneuver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Panerai, RB Univ Leicester, Leicester Royal Infirm, Div Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW Leics, England
Citazione:
R.B. Panerai et al., "Cerebral blood flow velocity response to induced and spontaneous sudden changes in arterial blood pressure", AM J P-HEAR, 280(5), 2001, pp. H2162-H2174

Abstract

The influence of different types of maneuvers that can induce sudden changes of arterial blood pressure (ABP) on the cerebral blood flow velocity (CBFV) response was studied in 56 normal subjects (mean age 62 yr, range 23-80). ABP was recorded in the finger with a Finapres device, and bilateral recordings of CBFV were performed with Doppler ultrasound of the middle cerebral arteries. Recordings were performed at rest (baseline) and during the thigh cuff test, lower body negative pressure, cold pressor test, hand grip, and Valsalva maneuver. From baseline recordings, positive and negative spontaneous transients were also selected. Stability of PCO2 was monitored withtranscutaneous measurements. Dynamic autoregulatory index (ARI), impulse, and step responses were obtained for 1-min segments of data for the eight conditions by fitting a mathematical model to the ABP-CBFV baseline and transient data (Aaslid's model) and by the Wiener-Laguerre moving-average method. Impulse responses were similar for the right- and left-side recordings, and their temporal pattern was not influenced by type of maneuver. Step responses showed a sudden rise at time 0 and then started to fall back to their original level, indicating an active autoregulation. ARI was also independent of the type of maneuver, giving an overall mean of 4.7 +/- 2.9 (n = 602 recordings). Amplitudes of the impulse and step responses, however, were significantly influenced by type of maneuver and were highly correlated with the resistance-area product before the sudden change in ABP (r = 20.93, P< 0.0004). These results suggest that amplitude of the CBFV step response is sensitive to the point of operation of the instantaneous ABP-CBFV relationship, which can be shifted by different maneuvers. Various degrees of sympathetic nervous system activation resulting from different ABP-stimulatingmaneuvers were not reflected by CBFV dynamic autoregulatory responses within the physiological range of ABP.

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Documento generato il 27/11/20 alle ore 01:27:36