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Titolo:
Parameters of red blood cell aggregation as correlates of the inflammatorystate
Autore:
Ben Ami, R; Barshtein, G; Zeltser, D; Goldberg, Y; Shapira, I; Roth, A; Keren, G; Miller, H; Prochorov, V; Eldor, A; Berliner, S; Yedgar, S;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biochem, IL-91120 Jerusalem,Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 L-91120 Jerusalem,Israel Sourasky Med Ctr, Dept Internal Med, IL-64239 Tel Aviv, Israel Sourasky Med Ctr Tel Aviv Israel IL-64239 Med, IL-64239 Tel Aviv, Israel Sourasky Med Ctr, Dept Cardiol, IL-64239 Tel Aviv, Israel Sourasky Med Ctr Tel Aviv Israel IL-64239 iol, IL-64239 Tel Aviv, Israel Sourasky Med Ctr, Dept Hematol, IL-64239 Tel Aviv, Israel Sourasky Med Ctr Tel Aviv Israel IL-64239 tol, IL-64239 Tel Aviv, Israel
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: H1982 - H1988
SICI:
0363-6135(200105)280:5<H1982:PORBCA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPUTERIZED IMAGE-ANALYSIS; C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; FLOW; ERYTHROCYTES; RHEOLOGY; ORGANIZATION; KINETICS; SEPSIS; ANGINA;
Keywords:
acute-phase response; aggregate size distribution; shear stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yedgar, S Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biochem, IL-91120 Jerusalem,Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 rusalem,Israel
Citazione:
R. Ben Ami et al., "Parameters of red blood cell aggregation as correlates of the inflammatorystate", AM J P-HEAR, 280(5), 2001, pp. H1982-H1988

Abstract

To identify clinically relevant parameters of red blood cell (RBC) aggregation, we examined correlations of aggregation parameters with C-reactive protein and fibrinogen in unstable angina (UA), acute myocardial infarction (AMI), and bacterial infection (BI). Aggregation parameters were derived from the distribution of RBC population into aggregate sizes (cells per aggregate) and changing of the distribution by flow-derived shear stress. Increased aggregation was observed in the following order: UA, AMI, and BI. The best correlation was obtained by integration of large aggregate fraction as afunction of shear stress. To differentiate plasmatic from cellular factorsin RBC aggregation, we determined the aggregation in the presence and absence of plasma and formulated a "plasma factor" (PF) ranging from 0 to 1. InAMI the enhanced aggregation was entirely due to PF (PF = 1), whereas in UA and BI it was due to both plasmatic and cellular factors (0 less than or equal to PF less than or equal to 1). It is proposed that clinically relevant parameters of RBC aggregation should express both RBC aggregate size distribution and aggregate resistance to disaggregation and distinguish between plasmatic and cellular factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:18:31