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Titolo:
Accuracy of echocardiographic estimates of left ventricular mass in mice
Autore:
Collins, KA; Korcarz, CE; Shroff, SG; Bednarz, JE; Fentzke, RC; Lin, H; Leiden, JM; Lang, RM;
Indirizzi:
Univ Chicago, Med Ctr, Noninvas Cardiac Imaging Lab, Chicago, IL 60637 USAUniv Chicago Chicago IL USA 60637 diac Imaging Lab, Chicago, IL 60637 USA Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Bioengn, Pittsburgh, PA 15261 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 280, anno: 2001,
pagine: H1954 - H1962
SICI:
0363-6135(200105)280:5<H1954:AOEEOL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TWO-DIMENSIONAL ECHOCARDIOGRAPHY; TRANSTHORACIC ECHOCARDIOGRAPHY; NONINVASIVE ASSESSMENT; NECROPSY VALIDATION; CARDIAC-FUNCTION; MOUSE; CARDIOMYOPATHY; ABNORMALITIES;
Keywords:
disease models; echocardiography; methods;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lang, RM Univ Chicago, Med Ctr, Noninvas Cardiac Imaging Lab, MC 5084,5841S Maryland Ave, Chicago, IL 60637 USA Univ Chicago MC 5084,5841 S MarylandAve Chicago IL USA 60637 USA
Citazione:
K.A. Collins et al., "Accuracy of echocardiographic estimates of left ventricular mass in mice", AM J P-HEAR, 280(5), 2001, pp. H1954-H1962

Abstract

Genetically modified mice have created the need for accurate noninvasive left ventricular mass (LVM) measurements. Recent technical advances provide two-dimensional images adequate for LVM calculation using the area-length method, which in humans is more accurate than M-mode methods. We compared the standard M-mode and area-length methods in mice over a wide range of LV sizes and weights (62-210 mg). Ninety-one CD-1 mice (38 normal, 44 aortic banded, and 9 inherited dilated cardiomyopathy) were imaged transthoracically(15 MHz linear transducer, 120 Hz). Compared with necropsy weights, area-length measurements showed higher correlation than the M-mode method (r = 0.92 vs. 0.81), increased accuracy (bias +/- SD: 1.4 +/- 27.1% vs. 36.7 +/- 51.6%), and improved reproducibility. There was no significant difference between end-systolic and end-diastolic estimates. The truncated ellipsoid estimation produced results similar in accuracy to the area-length method. Whereas current echocardiographic technology can accurately and reproducibly estimate LVM with the two-dimensional, area-length formula in a variety of mouse models, additional technological improvements, rather than refinement of geometric models, will likely improve the accuracy of this methodology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:04:52