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Titolo:
The effect of nonsteroidal anti-inflammatory drugs on the use of gastroprotective medication in people with arthritis
Autore:
Lapane, KL; Spooner, JJ; Pettitt, D;
Indirizzi:
Brown Univ, Sch Med, Ctr Gerontol & Hlth Care Res, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 lth Care Res, Providence, RI 02912 USA Brown Univ, Sch Med, Dept Community Hlth, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 mmunity Hlth, Providence, RI 02912 USA Pfizer Pharmaceut Inc, Outcomes Res, New York, NY USA Pfizer Pharmaceut Inc New York NY USA nc, Outcomes Res, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL OF MANAGED CARE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 402 - 408
SICI:
1088-0224(200104)7:4<402:TEONAD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIINFLAMMATORY DRUGS; RHEUMATOID-ARTHRITIS; GASTROINTESTINAL TOXICITY; OSTEOARTHRITIS; COHORT; COSTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lapane, KL Brown Univ, Sch Med, Ctr Gerontol & Hlth Care Res, Box G-B222,171 Meeting St, Providence, RI 02912 USA Brown Univ Box G-B222,171 Meeting St Providence RI USA 02912 SA
Citazione:
K.L. Lapane et al., "The effect of nonsteroidal anti-inflammatory drugs on the use of gastroprotective medication in people with arthritis", AM J M CARE, 7(4), 2001, pp. 402-408

Abstract

Objective: To estimate the incidence of gastroprotective medication use among users and nonusers of prescription nonsteroidal anti-inflammatory drugs(NSAIDs) who have arthritis. Study Design: A retrospective cohort study. Patients and Methods: We used the Protocare Sciences proprietary Managed Care Organization database, which contains data on more than 3 million lives, to identify 57,136 patients given an initial diagnosis of osteoarthritis (OA; International Classification of Disease, Ninth Revision, Clinical Modification [ICD-9-CM] codes: 715, 721.0, 721.3, or 721.9) or rheumatoid arthritis (RA; ICD-9-CM codes: 714.0, 714.1, 714.2 or 714.9); the diagnoses weremade during inpatient or outpatient medical encounters occurring between October 1, 1993, and September 30, 1997. The duration of therapy was calculated as the sum of the total number of days of receipt of all prescriptions during the year. The prescribed daily dose was determined by multiplying the drug dose by the number of pills dispensed and then dividing the product by the number of days supplied, as noted in the pharmacy records. Results: During the year after NSAID initiation, 27% of people with RA and12% of those with OA were chronic NSAID users. NSAID users with RA were 4 times as likely as NSAID nonusers with RA to begin using a gastroprotectiveagent within the first year; NSAID users with OA were twice as likely as nonusers with OA to do so. Conclusion: The use of gastroprotective agents during the first year afterNSAID initiation for the treatment of arthritis was greater than their useby those who did not take NSAIDs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:44:22