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Titolo:
High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype
Autore:
Wong, BCY; Wang, WH; Berg, DE; Fung, FMY; Wong, KW; Wong, WM; Lai, KC; Cho, CH; Hui, WM; Lam, SK;
Indirizzi:
Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples RChina Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples RChina Univ Hong Kong, Queen Mary Hosp, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 l Microbiol, St Louis, MO 63110 USA
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 4, volume: 15, anno: 2001,
pagine: 493 - 503
SICI:
0269-2813(200104)15:4<493:HPOMIB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE STRAIN COLONIZATION; DIFFERENT GASTRIC SITES; PEPTIC-ULCER DISEASE; TRIPLE THERAPY; DUODENAL-ULCER; DNA PATTERNS; RESISTANCE; SINGLE; RDXA; CLARITHROMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, BCY Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
B.C.Y. Wong et al., "High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype", ALIM PHARM, 15(4), 2001, pp. 493-503

Abstract

Background: Diversity in metronidazole susceptibility and genotypes of Helicobacter pylori have been reported with varying results in different areas. Aims: To investigate the prevalence of multiple strain infection in a symptomatic Chinese population and to determine the metronidazole susceptibility pattern and genotypic characteristics of these infecting strains. Methods: Gastric biopsies from antrum, body and cardia were taken during upper endoscopy in symptomatic patients referred to our department. Pooled cultures and single colony isolates were obtained and tested for metronidazole susceptibility and random amplified polymorphic DNA (RAPD) fingerprint patterns. Results: A total of 461 isolates were successfully cultured from 46 patients. Fifty-seven per cent of subjects had metronidazole-resistant strains. Among them. 77% carried a mixture of sensitive and resistant strains, nan-uniformly distributed in the gastric mucosa. Mixed genotypes were found by RAPD typing in 24% of subjects. These did not correlate with the metronidazole susceptibility/resistance pattern. Conclusion: H. pylori infections with mixed metronidazole sensitive/resistant strains and mixed genotypes are common in Hong Kong. This makes it prudent to use bacterial strains from several biopsy sites when testing for traits such as drug resistance or virulence in relation to disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:50:42