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Titolo:
Surgical treatment of malignant schwannomas (malignant tumor of nerve sheath origin MTNSO) of the thorax
Autore:
Kruger, M; Uschinsky, K; Engelmann, C;
Indirizzi:
Fachkrankenhaus Lungenheilkunde & Thoraxchirurg, Thoraxchirurg Klin, Berlin, Germany Fachkrankenhaus Lungenheilkunde & Thoraxchirurg Berlin Germany Germany
Titolo Testata:
ZENTRALBLATT FUR CHIRURGIE
fascicolo: 3, volume: 126, anno: 2001,
pagine: 223 - 228
SICI:
0044-409X(2001)126:3<223:STOMS(>2.0.ZU;2-8
Fonte:
ISI
Lingua:
GER
Soggetto:
NEUROFIBROMATOSIS; MEDIASTINUM; PATIENT;
Keywords:
malignant schwannoma; MTNSO; surgical treatment; results;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Engelmann, C Fachklin Lungenkrankheiten & Thoraxchirurg Berlin, Karower Str 11, D-13125Berlin, Germany Fachklin Lungenkrankheiten & Thoraxchirurg Berlin Karower Str 11 Berlin Germany D-13125
Citazione:
M. Kruger et al., "Surgical treatment of malignant schwannomas (malignant tumor of nerve sheath origin MTNSO) of the thorax", ZBL CHIR, 126(3), 2001, pp. 223-228

Abstract

The objective of this study is to evaluate the results after surgical treatment of malignant tumors arising from the peripheral nerves of the thorax under consideration of adjuvant therapy modalities. Patients and methods: Between 1988 and 1998, 9 patients (6 males, 3 females) underwent surgical treatment for MTNSO and 35 pts. for benign neurogenicrumors. The mean age in patients with malignant tumors was 45 years (range, 25 to 73 years). 3 pts. with MTNSO (33.3 %) had neurofibromatosis (von Recklinghausen's syndrome) compared to 8.6 % (3/35) in patients with benign neurogenic tumors. Results: In patients with MTNSO partial chest wall resections (n = 4) including sternectomy (n = 1), lung resections (n = 2), paravertebral (n = 1) and mediastinal tumor resection (n = 1) and palliative resection of pleural recurrence (n = 1) were performed. Radical resection was achieved in 5 pts. (55.5 %). There was no postoperative mortality. 3 patients (33.3 %) had postoperative complications: wound infection (n=2) and wound dehiscence due to fall with consequent pleural infection (n = 1). Adjuvant therapy was perfomed in two pts. (adjuvant radiotherapy/chemotherapy for metastatic diseasen = 1; adjuvant chemotherapy/adjuvant radiotherapy after resection of recurrent tumor n = 1). Early recurrence is documented in 2 pts. (after 3 and 6months). Two pts. are alive and free of disease at three years, and the patient after sternectomy with recurrent disease at 20 months. Three pts. died 8, 9 and 26 months after the primary surgical procedure. The first postoperative examination (at three months) in the remaining patient showed no evidence for recurrent disease. Conclusion: Patients with MTNSO have an unfavourable prognosis and local recurrence is frequent even after radical surgical therapy. Therefore an adjuvant treatment in these patients may be justified, even if the value of these therapy modalities is not proved yet. A tumor-free long-term survival especially after complete surgical resection is possible in selected cases.

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Documento generato il 04/04/20 alle ore 00:18:34