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Titolo:
Marek's disease virus down-regulates surface expression of MHC (B complex)class 1 (BF) glycoproteins during active but not latent infection of chicken cells
Autore:
Hunt, HD; Lupiani, B; Miller, MM; Gimeno, I; Lee, LF; Parcells, MS;
Indirizzi:
ARS, USDA, Avian Dis & Oncol Lab, E Lansing, MI 48863 USA ARS E Lansing MI USA 48863 Avian Dis & Oncol Lab, E Lansing, MI 48863 USA City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Biol, Duarte, CA 91010 USA City Hope Natl Med Ctr Duarte CA USA 91010 Mol Biol, Duarte, CA 91010 USA Univ Complutense, Fac Vet, Dept Patol Anim 2, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 atol Anim 2, E-28040 Madrid, Spain Univ Arkansas, Poultry Sci Ctr, Ctr Excellence Poultry Sci, Fayetteville, AR 72701 USA Univ Arkansas Fayetteville AR USA 72701 y Sci, Fayetteville, AR 72701 USA
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 282, anno: 2001,
pagine: 198 - 205
SICI:
0042-6822(20010330)282:1<198:MDVDSE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PROCESSING TAP; T-LYMPHOCYTE RESPONSE; UNIQUE SHORT REGION; CLASS-I MOLECULES; HEAVY-CHAINS; HERPESVIRUS; GENES; LINE; MDV; MUTANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hunt, HD ARS, USDA, Avian Dis & Oncol Lab, 3606 E Mt Hope Rd, E Lansing, MI 48863 USA ARS 3606 E Mt Hope Rd E Lansing MI USA 48863 ansing, MI 48863 USA
Citazione:
H.D. Hunt et al., "Marek's disease virus down-regulates surface expression of MHC (B complex)class 1 (BF) glycoproteins during active but not latent infection of chicken cells", VIROLOGY, 282(1), 2001, pp. 198-205

Abstract

Infection of chicken cells with three Marek's disease Virus (MDV) serotypes interferes with expression of the major histocompatibility complex (MHC or B complex) class I (BF) glycoproteins. BF surface expression is blocked after infection of OU2 cells with MDV serotypes 1, 2, and 3. MDV-induced T-cell tumors suffer a nearly complete loss of cell surface BF upon virus reactivation with 5-bromo-2'-deoxyuridine (BUdR). The recombinant virus (RB1BUS2gfp Delta) transforming the MDCC-UA04 cell line expresses green fluorescent protein (GFP) during the immediate early phase of viral gene expression. Of the UA04 cells induced to express the immediate early GFP, approximately60% have reduced levels of BF expression. All of the reactivated UA04 and MSB1 tumor cells expressing the major early viral protein pp38 display reduced revels of BF. Thus, BF down-regulation begins in the immediate early phase and is complete by the early phase of viral gene expression. The intracellular pool of BF is not appreciably affected, indicating that the likely mechanism is a block in BF transport and not the result of transcriptional or translational regulation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 22:54:25