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Titolo:
Neurological diseases and viral dynamics in the brains of neonatally bornadisease virus-infected gerbils
Autore:
Watanabe, M; Lee, BJ; Kamitani, W; Kobayashi, T; Taniyama, H; Tomonaga, K; Ikuta, K;
Indirizzi:
Osaka Univ, Res Inst Microbial Dis, Dept Virol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Virol, Suita, Osaka 5650871, Japan Rakuno Gakuen Univ, Sch Vet Med, Dept Pathol, Ebetsu, Hokkaido 0698501, Japan Rakuno Gakuen Univ Ebetsu Hokkaido Japan 0698501 Hokkaido 0698501, Japan
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 282, anno: 2001,
pagine: 65 - 76
SICI:
0042-6822(20010330)282:1<65:NDAVDI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE; RABIES VIRUS; BDV RNA; ANTIBODIES; RATS; PROTEINS; ANTIGENS; HORSES; DAMAGE; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Tomonaga, K Osaka Univ, Res Inst Microbial Dis, Dept Virol, 3-1 Yamadaoka,Suita, Osaka 5650871, Japan Osaka Univ 3-1 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
M. Watanabe et al., "Neurological diseases and viral dynamics in the brains of neonatally bornadisease virus-infected gerbils", VIROLOGY, 282(1), 2001, pp. 65-76

Abstract

Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that causes a chronic neurological disease in a wide variety of animal species. Todevelop a better understanding of the correlation between neurological disorders caused by BDV infection and virus distribution in the brain, we investigated viral dynamics in the central nervous system (CNS) of neonatally BDV-infected gerbils during the late stage of infection. Despite the severe symptoms and aggressive proliferation of BDV in the infected gerbils, no apparent neuroanatomical abnormalities or neuronal cell loss was observed in the infected gerbil brain. Furthermore, no or only minimal infiltration wasobserved in the infected gerbil brain. By in situ hybridization and real-time PCR analyses, we demonstrated that the predominant area of expression of BDV mRNA, as well as the protein, was shifted in the brain in associationwith progression of disease. In nondiseased gerbils, the virus replicationwas predominantly detected in the cerebral cortex and hippocampus of the CNS. On the other hand, diseased animals showed a high level of expression in the lower brain stem and cerebellum, especially in Purkinje cell neurons. These observations suggested that significant replication of the virus in specific areas of the CNS is critical for development of the neurological disorders in BDV-infected neonatal gerbils, (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:30:25