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Titolo:
Apoptosis in ultrasound-produced threshold lesions in the rabbit brain
Autore:
Vykhodtseva, N; McDannold, N; Martin, H; Bronson, RT; Hynynen, K;
Indirizzi:
Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Radiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Tufts Univ, Sch Vet Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 ts Univ, Sch Vet Med, Boston, MA 02111 USA
Titolo Testata:
ULTRASOUND IN MEDICINE AND BIOLOGY
fascicolo: 1, volume: 27, anno: 2001,
pagine: 111 - 117
SICI:
0301-5629(200101)27:1<111:AIUTLI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; HEAT-INDUCED APOPTOSIS; PROGRAMMED CELL-DEATH; DNA STRAND BREAKS; FOCUSED ULTRASOUND; IONIZING-RADIATION; UBIQUITIN PATHWAY; MILD HYPERTHERMIA; IN-VIVO; FRAGMENTATION;
Keywords:
ultrasound; hyperthermia; temperature; apoptosis; thermal therapy; ultrasound surgery; bioeffect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Hynynen, K Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 115 USA
Citazione:
N. Vykhodtseva et al., "Apoptosis in ultrasound-produced threshold lesions in the rabbit brain", ULTRASOUN M, 27(1), 2001, pp. 111-117

Abstract

Focused ultrasound (US) surgery has been used to induce high temperature elevations in tissue to coagulate the proteins and kill the tissue. The introduction of noninvasive online temperature monitoring has made it possible to induce well-controlled thermal exposures. In this study, we used magnetic resonance imaging (MRI) thermometry to monitor thermal exposures near thethreshold of tissue damage, and then investigated if apoptosis was induced. Rabbit brains were sonicated with an eight-sector phased array to create a large region of uniform temperature elevation at the end of a 30-s sonication. Histological examination demonstrated that apoptosis was induced in some cells. At 4 h after the sonications, the apoptotic cells constituted 9 /- 7% of identifiable cells. By 48 h after the sonications, the number of apoptotic cells had increased up to 17 +/- 9%. The impact of this finding for therapy needs to be explored further. (E-mail: kullervo@bwh.harvard.edu)(C) 2001 World Federation for Ultrasound in Medicine & Biology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:57:49