Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications
Autore:
Segrest, JP; Harvey, SC; Zannis, V;
Indirizzi:
Univ Alabama, Med Ctr, Dept Med, Atherosclerosis Res Unit, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 s Res Unit, Birmingham, AL 35294 USA Univ Alabama, Med Ctr, Dept Biochem & Mol Biol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 & Mol Biol, Birmingham, AL 35294 USA Univ Crete, Sch Med, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 d, Heraklion 71110, Crete, Greece Univ Crete, Inst Mol Biol & Biotechnol, Heraklion 71110, Crete, Greece Univ Crete Heraklion Crete Greece 71110 l, Heraklion 71110, Crete, Greece Boston Univ, Sch Med, Cardiovasc Inst, Mol Genet Sect, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 nst, Mol Genet Sect, Boston, MA 02118 USA
Titolo Testata:
TRENDS IN CARDIOVASCULAR MEDICINE
fascicolo: 6, volume: 10, anno: 2000,
pagine: 246 - 252
SICI:
1050-1738(200008)10:6<246:DMMOAA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LECITHIN-CHOLESTEROL ACYLTRANSFERASE; BINDING CASSETTE TRANSPORTER-1; TRIGLYCERIDE-RICH LIPOPROTEINS; AMPHIPATHIC ALPHA-HELIX; RECEPTOR SR-BI; TANGIER-DISEASE; PLASMA LIPOPROTEINS; SELECTIVE UPTAKE; BELT MODEL; MUTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Segrest, JP Univ Alabama, Med Ctr, Dept Med, Atherosclerosis Res Unit, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Birmingham, AL 35294 USA
Citazione:
J.P. Segrest et al., "Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications", TREND CARD, 10(6), 2000, pp. 246-252

Abstract

The major apolipoprotein (apo) A-I containing lipoprotein, high- density lipoprotein, is a negative risk factor for cardiovascular disease. An atomicresolution molecular model for lipid-associated apo A-I was recently proposed in which two apo A-I molecules are wrapped belt-wise around a small discoidal patch of phospholipid bilayer. Because of its detailed predictions of lipid-associated apo A-I structure, this molecular belt model, if confirmed, provides a blueprint for understanding the molecular mechanisms of reverse cholesterol transport, and thus for the rational design of new classes of drugs for reversal of atherosclerosis and cardiovascular disease. The details and implications of the model are currently being explored by site-directed mutagenesis. (Trends Cardiovasc Med 2000;10:246-252). (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:44:00