Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes in hemostasis during treatment of hypertriglyceridemia with a dietrich in monounsaturated and n-3 polyunsaturated fatty acids in comparison with a low-fat diet
Autore:
Junker, R; Pieke, B; Schulte, H; Nofer, R; Neufeld, M; Assmann, G; Wahrburg, U;
Indirizzi:
Univ Munster, Inst Clin Chem & Lab Med, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 & Lab Med, D-48129 Munster, Germany Univ Munster, Inst Arteriosclerosis Res, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 lerosis Res, D-4400 Munster, Germany
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 5, volume: 101, anno: 2001,
pagine: 355 - 366
SICI:
0049-3848(20010301)101:5<355:CIHDTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; CORONARY HEART-DISEASE; VII COAGULANT ACTIVITY; K-DEPENDENT PROTEINS; MIDDLE-AGED MEN; PLASMA VISCOSITY; BLOOD-LIPIDS; RISK-FACTORS; MYOCARDIAL-INFARCTION; FIBRINOLYTIC-ACTIVITY;
Keywords:
hypertriglyceridemia; diet; hemostasis; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Junker, R Univ Munster, Inst Clin Chem & Lab Med, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48129 y
Citazione:
R. Junker et al., "Changes in hemostasis during treatment of hypertriglyceridemia with a dietrich in monounsaturated and n-3 polyunsaturated fatty acids in comparison with a low-fat diet", THROMB RES, 101(5), 2001, pp. 355-366

Abstract

High levels of fibrinogen, factor (F) VIIc, plasminogen activator inhibitor-1 (PAI-1), and plasma viscosity are associated with an increased coronaryrisk. As positive correlations of these parameters with triglycerides havebeen shown, the increased coronary risk associated with high levels of triglycerides may be assumed to be due to alterations within the hemostatic system. To reduce the coronary risk to which hypertriglyceridemic patients are exposed, dietary treatment is recommended; the optimal composition of such a diet is, however, a matter of debate. With regard to the effects on hemostasis, we compared in a sequential approach two diets for treatment of 25nonobese male patients (age, mean +/-S.D., 40.4 +/-8.7 years) with fastingtriglycerides >2.3 mmol/l. The first diet (high fat) was rich in monounsaturated fatty acids (MUFA) and marine n-3 polyunsaturated fatty acids (PUFA), whereas the second diet (low-fat) was rich in complex carbohydrates and dietary fiber. The high-fat diet induced a significant lowering of FIIc, FIXc, FXc, FVIIc, FVIIa, FXIIa, PAI-1, plasma viscosity, and platelet activity, but led to an increase in fibrinogen, whereas the low-fat diet lowered FXIIc values and induced a nonsignificant decrease in fibrinogen. Probands onthis diet had a slightly higher FVIIa and platelet activity than those on the high-fat diet. However, as all changes appeared to be within the normalrange of each hemostatic parameter, it remains to be clarified whether thelikely beneficial effects of the high-fat diet on most hemostatic factors are outweighed by the small increase in fibrinogen levels. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:19:06