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Titolo:
The pathology of dry eye
Autore:
Baudouin, C;
Indirizzi:
Ctr Hosp Natl Ophthalmol Quinze Vingts, Serv Ophthalmol 3, F-75012 Paris, France Ctr Hosp Natl Ophthalmol Quinze Vingts Paris France F-75012 aris, France Univ Paris 05, APHP, Hop Ambroise Pare, Boulogne, France Univ Paris 05 Boulogne France APHP, Hop Ambroise Pare, Boulogne, France
Titolo Testata:
SURVEY OF OPHTHALMOLOGY
, volume: 45, anno: 2001, supplemento:, 2
pagine: S211 - S220
SICI:
0039-6257(200103)45:<S211:TPODE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPRESSION CYTOLOGY SPECIMENS; HUMAN CONJUNCTIVAL EPITHELIUM; PRIMARY SJOGRENS-SYNDROME; LACRIMAL GLAND-FUNCTION; OCULAR SURFACE; INTERFERON-GAMMA; MEIBOMIAN GLAND; OPHTHALMIC PRESERVATIVES; ANTIGEN EXPRESSION; GOBLET CELLS;
Keywords:
conjunctiva; cornea; dry eye disease; inflammation; lacrimal gland; pathology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Baudouin, C Ctr Hosp Natl Ophthalmol Quinze Vingts, Serv Ophthalmol 3, 28 Rue Charenton, F-75012 Paris, France Ctr Hosp Natl Ophthalmol Quinze Vingts28 Rue Charenton Paris France F-75012
Citazione:
C. Baudouin, "The pathology of dry eye", SURV OPHTHA, 45, 2001, pp. S211-S220

Abstract

Homeostasis of the tear film involves delicate hormonal and neuronal regulatory mechanisms. The eye appears to be a target organ for sex hormones, particularly the androgens, as they modulate the immune system and trophic functions of the lacrimal glands and the functioning of the meihomian glands The cornea, lacrimal glands, mucous cells, and meibomian glands are all richly innervated, indicating the importance of nervous regulation in their function. Parasympathetic, sympathetic, and sensory innervation play complex stimulatory or inhibitory roles, and neuronal pathways interact via complexsurface results cascades. abnormalities at any point in these pathways cancause overall dysregulation of lacrimal function. Whatever the initial causes of dry eye, chronic dryness of the ocular surface results in inflammatory reactions and gradual destruction of the lacrimal glands and conjunctival epithelium. Once dry eye disease has developed, inflammation is the key mechanism of ocular surface injury, as both the cause and consequence of cell damage. In practice, dry eye can be associated with Sjogren's syndrome, allergies, infection, blepharitis, and preservative-containing eye drops. (Surv Ophthalmol 45(Suppl 2):S211-20, 2001. (C) 2001 by Elsevier Science Inc. All rights reserved).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:29:47