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Titolo:
Spinal cord blood flow changes following systemic hypothermia and spinal cord compression injury: an experimental study in the rat using Laser-Doppler flowmetry
Autore:
Westergren, H; Farooque, M; Olsson, Y; Holtz, A;
Indirizzi:
Uppsala Univ, Dept Neurosci, Neurosurg Unit, Uppsala, Sweden Uppsala UnivUppsala Sweden t Neurosci, Neurosurg Unit, Uppsala, Sweden Uppsala Univ, Dept Genet & Pathol, Neuropathol Lab, Uppsala, Sweden Uppsala Univ Uppsala Sweden & Pathol, Neuropathol Lab, Uppsala, Sweden
Titolo Testata:
SPINAL CORD
fascicolo: 2, volume: 39, anno: 2001,
pagine: 74 - 84
SICI:
1362-4393(200102)39:2<74:SCBFCF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN TEMPERATURE; CEREBRAL AUTOREGULATION; SECONDARY INJURY; TRAUMA; MODULATION; DISORDERS; APOPTOSIS; ISCHEMIA; EMPHASIS;
Keywords:
hypothermia; rat; spinal cord injury; blood-flow; Laser-Doppler;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Westergren, H Univ Uppsala Hosp, Dept Neurosurg, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 5 Uppsala, Sweden
Citazione:
H. Westergren et al., "Spinal cord blood flow changes following systemic hypothermia and spinal cord compression injury: an experimental study in the rat using Laser-Doppler flowmetry", SPINAL CORD, 39(2), 2001, pp. 74-84

Abstract

Study design: It is well known that changes of the body temperature as well as trauma influence the blood flow in the brain and spinal cord. However,there is still a lack of knowledge concerning the levels of blood flow changes, especially during hypothermia. Objectives: This investigation was carried out to examine the effects of systemic hypothermia and trauma on spinal cord blood flow (SCBF). Methods: Twenty-four rats were randomized either to thoracic laminectomy only (Th VII-IX) or to 35 g spinal cord compression trauma. The animals werefurther randomized to either constant normothermia (38 degreesC) or to a systemic cooling procedure, ie I eduction of the esophageal temperature from38 to 30 degreesC. SCBF was recorded 5 tnm caudal to the injury zone usingLaser-Doppler flowmetry which allows a non-invasive continuous recording of local changes in the blood flow. The autoregulation ability was tested atthe end of the experiments by inducing a 30-50 mmHg blood-pressure fall, using blood-withdrawal from the carotid artery. Results: The mean SCBF decreased 2.8% and 3.5% per centigrade reduction ofesophageal temperature in the animals sustained to hypothermia with and without trauma, respectively. This could be compared to a decrease of 0.2%/min when only trauma was applied. No significant differences were seen between the groups concerning auto regulatory ability. Conclusions: Our results indicate that the core temperature has a high impact on the SCBF independent of previous trauma recorded by Laser-Doppler flowmetry. This influence exceeds the response mediated by moderate compression trauma alone. Sponsorship: The study was supported by grants from the Laerdal foundation.

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Documento generato il 01/12/20 alle ore 08:15:23