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Titolo:
Perioperative radiotherapy and concurrent radiochemotherapy in rectal cancer
Autore:
Rodel, C; Sauer, R;
Indirizzi:
Univ Erlangen Nurnberg, Dept Radiat Therapy, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
SEMINARS IN SURGICAL ONCOLOGY
fascicolo: 1, volume: 20, anno: 2001,
pagine: 3 - 12
SICI:
8756-0437(200101/02)20:1<3:PRACRI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREOPERATIVE RADIATION-THERAPY; LOCALLY ADVANCED PRIMARY; EXTERNAL-BEAM IRRADIATION; TOTAL MESORECTAL EXCISION; HIGH-DOSE LEUCOVORIN; COLORECTAL-CANCER; ADJUVANT THERAPY; POSTOPERATIVE RADIOTHERAPY; INTRAOPERATIVE ELECTRON; PROGNOSTIC FACTORS;
Keywords:
colorectal neoplasms; colorectal surgery; radiotherapy, adjuvant; chemotherapy, adjuvant; combined modality therapy; survival;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Rodel, C Univ Erlangen Nurnberg, Dept Radiat Therapy, Univ Str 27, D-91054Erlangen, Germany Univ Erlangen Nurnberg Univ Str 27 Erlangen Germany D-91054 many
Citazione:
C. Rodel e R. Sauer, "Perioperative radiotherapy and concurrent radiochemotherapy in rectal cancer", SEM SURG ON, 20(1), 2001, pp. 3-12

Abstract

Combined modality treatment is the recommended standard adjuvant therapy for patients with locally advanced rectal cancer in the United States and Germany. During the last decade substantial progress has been made in treatment modalities, and surgical management currently includes a broad spectrum of operative procedures ranging from radical operations to innovative sphincter-preserving techniques. Specialized groups have reported excellent local control rates with total mesorectal excision (TME) alone. New and improved radiation techniques (conformal and intraoperative radiotherapy) and innovative schedules (protracted intravenous and chronomodulated infusion) and combinations (oxaliplatin and irinotecan) of chemotherapy may have the potential to further increase the therapeutic benefit of adjuvant treatment. Moreover, the basic issue of timing (pre- or postoperative) within a multimodal regimen is currently being addressed in prospective trials. Evidently there is a need to question the current monolithic approaches, which were established by studies conducted more than a decade ago. It is also under discussion whether to apply the same schedule of postoperative radiochemotherapy to all patients with stage II/III rectal cancer, or to give preoperative intensive short-course radiation according to the Swedish concept for all patients with resectable rectal cancer irrespective of tumor stage and treatment goal (e.g., sphincter preservation). This review discusses different irradiation settings in more recent and ongoing studies of perioperative radiotherapy for rectal cancer, and focuses on the issue of which patient should receive radiotherapy (if at all), and if so, how and when. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 17:30:56