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Titolo:
Role of infection and cytokines in the pathogenesis of chronic obstructivepulmonary disease
Autore:
Raza, MW; Bint, AT; Blackwell, CC;
Indirizzi:
Freeman Rd Hosp, Dept Microbiol, Newcastle Upon Tyne NE7 7DN, Tyne & Wear,England Freeman Rd Hosp Newcastle Upon Tyne Tyne & Wear England NE7 7DN r,England Royal Victoria Infirm, Dept Microbiol, Newcastle Upon Tyne NE1 4LP, Tyne &Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and Univ Edinburgh, Sch Med, Dept Med Microbiol, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland
Titolo Testata:
REVIEWS IN MEDICAL MICROBIOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 109 - 119
SICI:
0954-139X(200104)12:2<109:ROIACI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; RESPIRATORY SYNCYTIAL VIRUS; FACTOR-ALPHA PROMOTER; BUCCAL EPITHELIAL-CELLS; AIR-FLOW OBSTRUCTION; EXHALED NITRIC-OXIDE; CHRONIC-BRONCHITIS; CIGARETTE-SMOKING; LUNG-DISEASE; TNF-ALPHA;
Keywords:
chronic obstructive pulmonary disease; COPD; infection; cigarette smoking; genetic polymorphism; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Raza, MW Freeman Rd Hosp, Dept Microbiol, Newcastle Upon Tyne NE7 7DN, Tyne & Wear,England Freeman Rd Hosp Newcastle Upon Tyne Tyne & Wear England NE7 7DN
Citazione:
M.W. Raza et al., "Role of infection and cytokines in the pathogenesis of chronic obstructivepulmonary disease", REV MED MIC, 12(2), 2001, pp. 109-119

Abstract

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidityand mortality world-wide. The precise sequence of events in COPD is not completely understood. Inflammation in the airways has been unanimously seen by researchers as a pivotal factor, and cigarette smoking is, without doubt, the main cause. A large proportion of heavy smokers, however, does not suffer with COPD, suggesting a role of additional risk factors in pathogenesis. The inflammatory response to cigarette smoke and infectious agents is determined by the host's genetic composition. Cigarette smoking, by altering the surface milieu of respiratory mucosa and by causing immunosuppression, increases the susceptibility of individuals to infection with respiratory viral and bacterial pathogens. Virus infection has also been recognised as asusceptibility factor for secondary bacterial infection. An investigation into the role of individual genetic variations in inflammatory cell and cytokine production and non-host factors involved in COPD forms the basis of the development of more effective strategies to intervene in pathogenesis, progression and exacerbation of COPD. The aims of this article are to reviewthe evidence for predisposing factors for COPD, with a particular emphasison respiratory tract infections, and to examine those findings in relationto individual genetic variations and their interactions for induction of pro-inflammatory cytokine production in the respiratory tract. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:46:59