Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Managing chronic hepatitis C acquired through intravenous drug use
Autore:
Jowett, SL; Agarwal, K; Smith, BC; Craig, W; Hewett, M; Bassendine, DR; Gilvarry, E; Burt, AD; Basendine, MF;
Indirizzi:
Univ Newcastle Upon Tyne, Freeman Hosp, Liver Res Ctr, Newcastle Upon TyneNE1 7RU, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon TyneTyne & Wear England NE1 7RU Specialist Drug & Alcohol Unit, Newcastle Upon Tyne, Tyne & Wear, England Specialist Drug & Alcohol Unit Newcastle Upon Tyne Tyne & Wear England d
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 3, volume: 94, anno: 2001,
pagine: 153 - 158
SICI:
1460-2725(200103)94:3<153:MCHCAT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS-INFECTION; CLINICAL OUTCOMES; INTERFERON-ALPHA; UNITED-STATES; RIBAVIRIN; PLACEBO; PREVALENCE; TRIAL; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Basendine, MF Med Sch Newcastle Upon Tyne, Liver Res Ctr, 4th Floor,William Leech Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Med Sch Newcastle Upon Tyne 4th Floor,William Leech Bldg,Framlington PlNewcastle Upon Tyne Tyne & Wear England NE2 4HH
Citazione:
S.L. Jowett et al., "Managing chronic hepatitis C acquired through intravenous drug use", QJM-MON J A, 94(3), 2001, pp. 153-158

Abstract

We retrospectively reviewed the provision and uptake of hospital services for 253 current and ex-intravenous drug users with hepatitis C virus (HCV). Overall, 237 attended at least one clinic (mean age 32 years, 70% male, 43% on maintenance methadone); 81% had evidence of active viral replication and 137 agreed to a liver biopsy to assess disease severity. Of these 137, 24% had mild chronic hepatitis with a low risk of progression to cirrhosis, but 9% had cirrhosis (mean age 40 years, mean time since initial intravenous drug use 15.8 years). Only 50 of the 100 patients in whom antiviral therapy was indicated, commenced treatment; 18 (36%) have had a sustained virological response. The natural history or response to treatment of chronic HCVin those who acquire it through intravenous drug use is not different to that previously reported for post-transfusion HCV. However, a substantial proportion default from follow-up or decline further intervention. As intravenous drug use is now the main risk factor for acquisition of HCV, these data have implications for future delivery of care aimed at limiting the morbidity of chronic HCV, and limiting the spread of hepatitis C virus infectionamongst intravenous drug users.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:22:45