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Titolo:
Six-month outcomes for patients who switched to olanzapine treatment
Autore:
Noordsy, DL; OKeefe, C; Mueser, KT; Xie, HY;
Indirizzi:
Mental Hlth Ctr Greater Manchester, Manchester, NH USA Mental Hlth Ctr Greater Manchester Manchester NH USA Manchester, NH USA Dartmouth Med Sch, Hanover, NH 03756 USA Dartmouth Med Sch Hanover NH USA03756 uth Med Sch, Hanover, NH 03756 USA
Titolo Testata:
PSYCHIATRIC SERVICES
fascicolo: 4, volume: 52, anno: 2001,
pagine: 501 - 507
SICI:
1075-2730(200104)52:4<501:SOFPWS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASSERTIVE COMMUNITY TREATMENT; SEVERE MENTAL-ILLNESS; NEGATIVE SYMPTOMS; CLINICAL-TRIAL; DOUBLE-BLIND; SCHIZOPHRENIA; HALOPERIDOL; ANTIPSYCHOTICS; RISPERIDONE; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Noordsy, DL 1555 Elm St, Manchester, NH 03101 USA 1555 Elm St Manchester NH USA 03101 Manchester, NH 03101 USA
Citazione:
D.L. Noordsy et al., "Six-month outcomes for patients who switched to olanzapine treatment", PSYCH SERV, 52(4), 2001, pp. 501-507

Abstract

Objective: This study evaluated the outcomes of patients in a community mental health center who switched from treatment with another antipsychotic to olanzapine treatment. It also sought to determine whether simultaneous access to case management and psychosocial rehabilitation and olanzapine leads to enhanced functional improvement. Methods: Six-month outcomes for a consecutive series of 104 patients who switched from a conventional antipsychotic medication to olanzapine were evaluated. Forty-nine patients in the same treatment program who continued to take conventional antipsychotics were also monitored as a reference group. Outcomes of the group receiving olanzapine were compared with their own baseline status and with outcomes of the reference group. Results: At six months, patients in the olanzapine group demonstrated significant improvement over baseline across multiple measures of symptoms and psychosocial function. Compared with the reference group, the olanzapine group was more symptomatic at baseline and demonstrated significantly greater improvement at follow-up on the Brief Psychiatric Rating Scale and all subscales; Mini Psychiatric Rating Scale negative symptom, disorganization, anxiety, depression, and medication side effects items; and Clinical Global improvement scale and Case Manager's Rating Scale-Plus illness factors. There was a trend toward superior improvement in psychosocial functioning among patients in the olanzapine group that achieved significance when patients in acute relapse at baseline were excluded. Conclusions: Olanzapine is effective in managing markedly to severely ill patients with psychotic disorders in a community mental health center. Simultaneous treatment with olanzapine, case management, and psychosocial rehabilitation leads to enhanced functional improvement among nonrelapsing patients.

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Documento generato il 18/01/20 alle ore 10:34:05