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Titolo:
Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease
Autore:
Steiner, RA; Hohmann, JG; Holmes, A; Wrenn, CC; Cadd, G; Jureust, A; Clifton, DK; Luo, ML; Gutshall, M; Ma, SY; Mufson, EJ; Crawley, JN;
Indirizzi:
NIMH, Sect Behav Neuropharmacol, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 t Behav Neuropharmacol, Bethesda, MD 20892 USA Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA Univ Washington, Dept Zool, Seattle, WA 98195 USA Univ Washington SeattleWA USA 98195 on, Dept Zool, Seattle, WA 98195 USA Univ Washington, Grad Program Neurobiol & Behav, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 obiol & Behav, Seattle, WA 98195 USA Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 tet & Gynecol, Seattle, WA 98195 USA Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 7, volume: 98, anno: 2001,
pagine: 4184 - 4189
SICI:
0027-8424(20010327)98:7<4184:GTMDCA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITS ACETYLCHOLINE-RELEASE; FOREBRAIN CHOLINERGIC NEURONS; DOPAMINE-BETA-HYDROXYLASE; LONG-TERM POTENTIATION; BASAL FOREBRAIN; MUTANT MICE; VENTRAL HIPPOCAMPUS; LOCUS-CERULEUS; NORADRENERGIC NEURONS; BEHAVIORAL PHENOTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Crawley, JN NIMH, Sect Behav Neuropharmacol, Bldg 10,Room 4D11, Bethesda, MD 20892 USA NIMH Bldg 10,Room 4D11 Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
R.A. Steiner et al., "Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease", P NAS US, 98(7), 2001, pp. 4184-4189

Abstract

Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containingfibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition. We generated transgenic mice (CAL-tg) that overexpress galanin under the control of the dopamine beta -hydroxylase promoter to study the neurochemical and behavioral sequelae of a mouse model of galanin overexpression in AD. Overexpression of galanin was associated with a reduction in the number of identifiable neurons producing acetylcholine in the horizontal limb of the diagonal band. Behavioral phenotyping indicated that GAL-tgs displayed normal general health and sensory and motor abilities; however, CAL-tg mice showed selective performance deficits on the Morris spatial navigational task and the social transmission of food preference olfactory memory test. These results suggest that elevated expression of galanin contributes to the neurochemical and cognitive impairmentscharacteristic of AD.

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Documento generato il 06/04/20 alle ore 08:12:46