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Titolo:
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: Implications for human health
Autore:
Lasmezas, CI; Fournier, JG; Nouvel, V; Boe, H; Marce, D; Lamoury, F; Kopp, N; Hauw, JJ; Ironside, J; Bruce, M; Dormont, D; Deslys, JP;
Indirizzi:
CEA, Serv Neurovirol,Direct Sci Vivant, Dept Rech Med, Ctr Rech Serv SanteArmees, F-92265 Fontenay Aux Roses, France CEA Fontenay Aux Roses France F-92265 F-92265 Fontenay Aux Roses, France Hop Neurol Pierre Wertheimer, F-69003 Lyon, France Hop Neurol Pierre Wertheimer Lyon France F-69003 r, F-69003 Lyon, France Hop La Pitie Salpetriere, Neuropathol Lab, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 Lab, F-75013 Paris, France Western Gen Hosp, Creutzfeldt Jakob Dis Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland Inst Anim Hlth, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland Inst Anim Hlth Edinburgh Midlothian Scotland EH9 3JF Midlothian, Scotland
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 7, volume: 98, anno: 2001,
pagine: 4142 - 4147
SICI:
0027-8424(20010327)98:7<4142:AOTBSE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRION PROTEIN; NONHUMAN-PRIMATES; STRAIN VARIATION; VARIANT CJD; SCRAPIE; TRANSMISSION; VCJD; BSE; MICE; UK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Lasmezas, CI CEA, Serv Neurovirol,Direct Sci Vivant, Dept Rech Med, Ctr Rech Serv SanteArmees, 60-68 Ave Gen Leclerc,BP 6, F-92265 Fontenay Aux Roses, France CEA 60-68 Ave Gen Leclerc,BP 6 Fontenay Aux Roses France F-92265
Citazione:
C.I. Lasmezas et al., "Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: Implications for human health", P NAS US, 98(7), 2001, pp. 4142-4147

Abstract

There is substantial scientific evidence to support the notion that bovinespongiform encephalopathy (BSE) has contaminated human beings, causing variant Creutzfeldt-Jakob disease (vCJD). This disease has raised concerns about the possibility of an iatrogenic secondary transmission to humans, because the biological properties of the primate-adapted BSE agent are unknown. We show that (i) BSE can be transmitted from primate to primate by intravenous route in 25 months, and (ii) an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route. Strain typing in mice demonstrates that the BSE agent adapts to macaques in the same way as it does to humans and confirms that the BSE agent is responsible for vCJD not only in the United Kingdom but also in France. The agent responsible for French iatrogenic growth hormone-linked CJD taken as a control is very different from vCJD but is similar to that found in one case of sporadic CJD and one sheep scrapie isolate. These data will be key in identifying the origin of human cases of prion disease, including accidental vCJD transmission, and could provide bases for vCJD risk assessment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 15:08:58