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Titolo:
Cell autonomous regulation of multiple dishevelled-dependent pathways by mammalian Nkd
Autore:
Yan, D; Wallingford, JB; Sun, TQ; Nelson, AM; Sakanaka, C; Reinhard, C; Harland, RM; Fantl, WJ; Williams, LT;
Indirizzi:
Chiron Corp, Emeryville, CA 94608 USA Chiron Corp Emeryville CA USA 94608Chiron Corp, Emeryville, CA 94608 USA Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA UnivCalif Berkeley Berkeley CA USA 94720 ar Biol, Berkeley, CA 94720 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 7, volume: 98, anno: 2001,
pagine: 3802 - 3807
SICI:
0027-8424(20010327)98:7<3802:CAROMD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY EPITHELIAL-CELLS; XENOPUS EMBRYOS; SIGNALING PATHWAYS; BETA-CATENIN; PLANAR POLARITY; WNT PATHWAY; KINASE; PROTEIN; GASTRULATION; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, LT Chiron Corp, 4560 Horton St, Emeryville, CA 94608 USA Chiron Corp 4560 Horton St Emeryville CA USA 94608 94608 USA
Citazione:
D. Yan et al., "Cell autonomous regulation of multiple dishevelled-dependent pathways by mammalian Nkd", P NAS US, 98(7), 2001, pp. 3802-3807

Abstract

Genetic studies have identified Drosophila Naked Cuticle (Nkd) as an antagonist of the canonical Wnt/beta -catenin signaling pathway, but its mechanism of action remains obscure [Zeng, W,, Wharton, K, A., Jr., Mack, J. A., Wang, K., Gadbaw, M., et al. (2000) Nature (London) 403, 789-795]. Here we have cloned a cDNA encoding a mammalian homolog of Drosophila Nkd, mNkd, anddemonstrated that mNkd interacts directly with Dishevelled. Dishevelled isan intracellular mediator of both the canonical Wnt pathway and planar cell polarity (PCP) pathway. Activation of the c-Jun-N-terminal kinase has been implicated in the PCP pathway. We showed that mNkd acts in a cell-autonomous manner not only to inhibit the canonical Wnt pathway but also to stimulate c-Jun-N-terminal kinase activity. Expression of mNkd disrupted convergent extension in Xenopus, consistent with a role for mNkd in the PCP pathway. These data suggest that mNkd may act as a switch to direct Dishevelled activity toward the PCP pathway, and away from the canonical Wnt pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:00:40