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Titolo:
Insights into a plasma membrane signature
Autore:
Harvey, S; Zhang, Y; Landry, F; Miller, C; Smith, JW;
Indirizzi:
Burnham Inst, Canc Res Ctr, Program Cell Adhes, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 ram Cell Adhes, La Jolla, CA 92037 USA
Titolo Testata:
PHYSIOLOGICAL GENOMICS
fascicolo: 3, volume: 5, anno: 2001,
pagine: 129 - 136
SICI:
1094-8341(20010402)5:3<129:IIAPMS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE SEQUENCE TAGS; CARCINOMA CELL-LINES; PROTEIN EXPRESSION; BREAST-CANCER; DISEASE; IDENTIFICATION; TRANSFORMATION; INITIATION; ADHESION; ELECTROPHORESIS;
Keywords:
proteome; expression profiling; breast cancer; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, JW Burnham Inst, Canc Res Ctr, Program Cell Adhes, 10901 N Torrey Pines Rd, La Jolla, CA 92037 USA Burnham Inst 10901 N Torrey Pines Rd La Jolla CA USA 92037 7 USA
Citazione:
S. Harvey et al., "Insights into a plasma membrane signature", PHYSIOL GEN, 5(3), 2001, pp. 129-136

Abstract

The plasma membrane (PM) is an organized biological system that serves as a structural barrier and communication interface with the extracellular environment. Many basic questions regarding the PM as a system remain unanswered. In particular, we do not understand the scope of similarity and differences in protein expression at the PM. This study takes an initial step toward addressing these questions by comparing the PM proteomes of fibroblasts and mammary carcinoma cells. Three sets of proteins were revealed by the study. The first set comprises between 9 and 23% of all proteins at the PM and appears to be common to both fibroblasts and mammary carcinoma. A second group of proteins, comprising similar to 40% of the proteins at the PM, is tightly linked to cell lineage. The third set of proteins is unique to eachcell line and is independent of cell lineage. It is reasonable to hypothesize then, that this third group of proteins is responsible for unique aspects of cell behavior. In an effort to find proteins linked to the metastaticphenotype, we identified several proteins that are uniquely expressed at the PM of the metastatic MDA-MB-435 cells. These proteins have functions ranging from cell adhesion to the regulation of translation and the control ofoxidant stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:41:26