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Titolo:
Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons
Autore:
Mehta, A; Eberle-Wang, K; Chesselet, MF;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 68, anno: 2001,
pagine: 347 - 353
SICI:
0091-3057(200102)68:2<347:IMODAL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; BASAL GANGLIA; SUBTHALAMIC NUCLEUS; DOPAMINERGIC STIMULATION; VENTROLATERAL STRIATUM; FUNCTIONAL-ANATOMY; RAT-BRAIN; 5,7-DIHYDROXYTRYPTAMINE; SUPERSENSITIVITY; MECHANISMS;
Keywords:
5-HT2C; 1-(m-chlorophenyl)piperazine (m-CPP); 5,7-dihydroxytryptamine (5,7-DHT); 5-hydroxytryptamine (5-HT); subthalamic nucleus; basal ganglia; tardive dyskinesia; movement disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Chesselet, MF Univ Calif Los Angeles, Sch Med, Dept Neurol, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
A. Mehta et al., "Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons", PHARM BIO B, 68(2), 2001, pp. 347-353

Abstract

Peripheral administration of the 5-hydroxytryptamine (5-HT)(2C/1B) agonist1-(m-chlorophenyl)piperazine (m-CPP) produces abnormal orofacial movementsin rats. We have previously shown that this behavior is mediated by 5-HT2Creceptors in the subthalamic nucleus [Neuroscience 72 (1996) 117]. The present studies examined this effect after serotonin depletion to determine whether removal of endogenous serotonin affected this behavioral response and/or subthalamic 5-HT2C receptors. Rats received an intraventricular infusion of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT, 100 mg/10 mi) or vehicle after desipramine pretreatment (25 mg/kg ip). The efficacy of serotonindepletion was confirmed by a decrease in serotonin uptake sites measured by autoradiography. Oral dyskinesia induced by peripheral administration of m-CPP (1.0 mg/kg ip) was markedly increased in lesioned rats compared to sham-operated controls 4 and 8 but not 12 days after the lesion. A subset of lesioned rats that displayed transient seizures after m-CPP injection did not prevent the measurement of oral dyskinesia during the observation period. No differences in 5-HT2C receptor levels were found with ligand-binding autoradiography in the subthalamic nucleus, or in other brain regions that express this receptor, in rats sacrificed 5 days following 5,7-DHT lesions. The data indicate that lesion of serotonergic neurons in adult rats inducesa transient increase in motor responses mediated by subthalamic 5-HT2C receptors. These data suggest that functional alterations in serotonergic transmission in the subthalamic nucleus may be involved in the pathophysiology of hyperkinetic movement disorders. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 23/01/20 alle ore 18:21:58