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Titolo:
Modulation of cocaine's discriminative stimulus effects by dopamine D-1 agonists in rhesus monkeys
Autore:
Sinnott, RS; Nader, MA;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Ctr Neurobiol Invest Drug Abuse, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 68, anno: 2001,
pagine: 301 - 309
SICI:
0091-3057(200102)68:2<301:MOCDSE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
D1 RECEPTOR AGONISTS; SQUIRREL-MONKEYS; PHARMACOLOGICAL CHARACTERIZATION; ADENYLYL-CYCLASE; SEEKING BEHAVIOR; EFFICACY; ANTAGONISTS; SKF-38393; PRIMATES; HISTORY;
Keywords:
cocaine; dopamine; efficacy; drug discrimination; SKF 81297; SKF 38393; SCH 23390; rhesus monkeys;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Nader, MA Wake Forest Univ, Sch Med, Dept Physiol & Pharmacol, Ctr Neurobiol Invest Drug Abuse, Med Ctr Blvd, Winston Salem, NC 27157 USA Wake ForestUniv Med Ctr Blvd Winston Salem NC USA 27157 157 USA
Citazione:
R.S. Sinnott e M.A. Nader, "Modulation of cocaine's discriminative stimulus effects by dopamine D-1 agonists in rhesus monkeys", PHARM BIO B, 68(2), 2001, pp. 301-309

Abstract

Dopamine (DA) D-1 agonists are classified as high- or low-efficacy on the basis of in vitro functional measures as compared to DA. In monkeys self-administering cocaine, high-efficacy D-1 agonists have been shown to have reinforcing effects, while low-efficacy agonists do not. However, the relationship between D-1 agonist efficacy and cocaine-like discriminative stimulus effects, particularly in rhesus monkeys, is not clear. The present study investigated the discriminative stimulus effects of a high- (SE;F 81297) and a low-efficacy (SKF 38393) D-1 agonist in rhesus monkeys (n=4) trained to discriminate cocaine from saline using a two-lever drug discrimination procedure. In a second experiment, the effects of agonist pretreatments, as wellas pretreatment with a D-1 antagonist, on cocaine's discriminative stimulus effects were evaluated. SKF 81297 (0.01 - 1.7 mg/kg) fully substituted for cocaine in three of four animals ( >80% cocaine-appropriate responding), while SKF 38393 (0.3-10 mg/kg) occasioned <50% cocaine-appropriate responding in all subjects. When given as a pretreatment, neither agonist altered cocaine's discriminative stimulus effects at the doses tested. In contrast, the D-1 antagonist SCH 23390 attenuated cocaine's discriminative stimulus effects. These results indicate that D-1 agonists have cocaine-like discriminative stimulus effects in rhesus monkeys that are consistent with their invitro efficacies. However, when given in combination with cocaine, D-1 agonist efficacy does not appear to be a major factor in modifying cocaine's discriminative stimulus effects. <(c)> 2001 Elsevier Science Inc. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:00:17