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Titolo:
Exogenous cortisol exerts effects on the startle reflex independent of emotional modulation
Autore:
Buchanan, TW; Brechtel, A; Sollers, JJ; Lovallo, WR;
Indirizzi:
Vet Affairs Med Ctr, Behav Sci Labs 151A, Oklahoma City, OK 73104 USA Vet Affairs Med Ctr Oklahoma City OK USA 73104 klahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Oklahoma City, OK USA Univ Oklahoma Oklahoma City OK USA at & Behav Sci, Oklahoma City, OK USA Univ Dusseldorf, Inst Allgemeine Psychol, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ol, D-4000 Dusseldorf, Germany
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 68, anno: 2001,
pagine: 203 - 210
SICI:
0091-3057(200102)68:2<203:ECEEOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; GLUCOCORTICOID RECEPTORS; POTENTIATED STARTLE; CONDITIONED FEAR; ACOUSTIC STARTLE; MESSENGER-RNA; ANXIETY; CORTICOSTERONE; AMYGDALA; BRAIN;
Keywords:
cortisol; startle; emotion; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lovallo, WR Vet Affairs Med Ctr, Behav Sci Labs 151A, 921 NE 13th St, Oklahoma City, OK 73104 USA Vet Affairs Med Ctr 921 NE 13th St Oklahoma City OKUSA 73104
Citazione:
T.W. Buchanan et al., "Exogenous cortisol exerts effects on the startle reflex independent of emotional modulation", PHARM BIO B, 68(2), 2001, pp. 203-210

Abstract

Exogenous cortisol's modulation of the acoustic startle reflex (ASR) was tested alone and during exposure to affectively valenced photographs in healthy men and women. During nonmodulated startle, oral hydrocortisone had a biphasic dose effect, with 5 mg increasing and 20 mg decreasing, eyeblink reflex magnitude compared to placebo. During emotion modulation, 20 mg of hydrocortisone reduced reflex magnitude without affecting the usual pattern ofmodulation across positive, neutral, and negatively affective slides. Gender differences were not found in either relationship. These findings illustrate dose-dependent effects of cortisol on the startle pathway independent of emotional state and consistent across genders. (C) 2001 Elsevier ScienceInc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:51:12