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Titolo:
MK801 increases feeding and decreases drinking in nondeprived, freely feeding rats
Autore:
Jahng, JW; Houpt, TA;
Indirizzi:
Yonsei Univ, Coll Med, Dept Pharmacol, Seoul, South Korea Yonsei Univ Seoul South Korea l Med, Dept Pharmacol, Seoul, South Korea Florida State Univ, Dept Sci Biol, Tallahassee, FL 32306 USA Florida StateUniv Tallahassee FL USA 32306 ol, Tallahassee, FL 32306 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 2, volume: 68, anno: 2001,
pagine: 181 - 186
SICI:
0091-3057(200102)68:2<181:MIFADD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INGESTIVE BEHAVIOR; MESSENGER-RNA; RECEPTOR; EXPRESSION; MK-801; SATIATION; BLOCKADE; NEURONS; NMDAR1;
Keywords:
NMDA antagonist; food intake; ingestion; intermeal interval; drinking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Houpt, TA Yonsei Univ, Coll Med, Dept Pharmacol, Seoul, South Korea YonseiUniv Seoul South Korea t Pharmacol, Seoul, South Korea
Citazione:
J.W. Jahng e T.A. Houpt, "MK801 increases feeding and decreases drinking in nondeprived, freely feeding rats", PHARM BIO B, 68(2), 2001, pp. 181-186

Abstract

The noncompetitive NMDA receptor antagonist MK801 has been reported to increase food intake in rats during scheduled test meals of palatable foods orafter food deprivation, but not in nondeprived rats given rodent chow. To determine if MK801 has an effect on spontaneous meals, MK801 (100 mug/kg) was administered 15 min prior to dark onset to nondeprived rats maintained on powdered rodent chow, and spontaneous food and water access was measured. MK801 increased the length of the first meal and the amount of time spent feeding within the meal. Conversely, MK801 decreased the length and size ofthe first drinking bout. MK801 did not alter the latency to the first mealor drinking bout, nor the intervals between successive meals or bouts. Theeffects of MK801 on feeding and drinking bouts were partially confirmed bymeasuring total chow and water intake over the first 2 h of the dark period. Thus, acute MK801 can significantly alter spontaneous chow feeding and drinking in nondeprived rats when administered prior to dark onset. (C) 2001Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:00:06